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製品番号: HY-169096

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DPP-21

DPP-21 is an inhibitor of tubulin polymerization (IC₅₀: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC₅₀s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax).

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CAS 番号: 2924883-83-8
分子式: C₁₇H₁₆N₄S
分子量:308.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DPP-21 構造式

CAS 番号: 2924883-83-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	11.69 nM Compound: DPP-21	Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
HCT-116	IC₅₀	0.38 nM Compound: DPP-21	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
HeLa	IC₅₀	5.37 nM Compound: DPP-21	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
HepG2	IC₅₀	9.37 nM Compound: DPP-21	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
MCF7	IC₅₀	9.53 nM Compound: DPP-21	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
NCI-H23	IC₅₀	8.94 nM Compound: DPP-21	Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]

化学情報

CAS 番号 2924883-83-8
分子量 308.40
分子式 C₁₇H₁₆N₄S
SMILES

CC1=NC(N(C2=CC3=C(N(C=C3)C)C=C2)C)=C4SC=CC4=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xu C, et al. Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma. Eur J Med Chem. 2024 Nov 5;277:116791. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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