DSPE-PEG2000-AC

DSPE-PEG2000-AC is mainly used for the preparation and research of hydrogels and cross-linked polymer networks.
Structural composition and the role of each component:
(1) DSPE: 1,2-distearate-sn-glycerol-3-phosphoethanolamine, containing two saturated C18 stearoyl chains, is an amphiphilic phospholipid. As a lipid anchoring group, it can stably insert into the lipid bilayer of liposomes or lipid nanoparticles, anchoring the entire molecule to the carrier surface;
(2) PEG2000: Polyethylene glycol with a molecular weight of approximately 2000 Da, acting as a hydrophilic spacer arm, can enhance the water solubility and steric hindrance of the molecule, improve the stability of the carrier and prolong its circulation time in vivo, while extending the terminal ligand away from the carrier surface, which is beneficial for the recognition and binding of ligands and receptors;
(3) AC acrylate group: Acrylate is a polymerizable functional group containing carbon-carbon double bonds, which can participate in free radical polymerization and thiol-ene reactions to form cross-linked polymer networks and hydrogels.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.