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製品番号: HY-145303

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DX2-201

1 Cited Publications

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DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC₅₀ of 312 nM. DX2-201 has anticancer effects.

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CAS 番号: 2749554-00-3
分子式: C₁₈H₂₈N₂O₆S₂
分子量:432.55

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DX2-201 構造式

CAS 番号: 2749554-00-3

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生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
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生物活性

製品説明

DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC₅₀ of 312 nM. DX2-201 has anticancer effects^[1].

IC₅₀ & Target

IC50: 312 nM (OXPHOS complex I)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	0.6 μM Compound: 2; DX2-201	Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	GI₅₀	0.6 μM Compound: 1	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for overnight in glucose-containing medium followed by compound addition and measured after 7 days by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for overnight in glucose-containing medium followed by compound addition and measured after 7 days by MTT assay	[PMID: 35167303]
MIA PaCa-2	IC₅₀	>10 μM Compound: 2; DX2-201	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in galactose-containing medium by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in galactose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	IC₅₀	0.09 μM Compound: 2; DX2-201	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in glucose-containing medium by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 3 days in glucose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	IC₅₀	0.4 μM Compound: 2; DX2-201	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 7 days in glucose-containing medium by MTT assay	[PMID: 34982568]
MIA PaCa-2	IC₅₀	118.5 nM Compound: 2; DX2-201	Inhibition of oxidative phosphorylation in human MIA PaCa-2 cells assessed as reduction in ATP production incubated for 24 hrs in galactose-containing medium by CellTiter-glo luminescence assay Inhibition of oxidative phosphorylation in human MIA PaCa-2 cells assessed as reduction in ATP production incubated for 24 hrs in galactose-containing medium by CellTiter-glo luminescence assay	[PMID: 34982568]

体外実験

DX2-201 (cmpound 2) potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS^[1].
DX2-201 depletes ATP production with an IC₅₀ value of 118.5 nM in the galactose-containing medium^[1].
DX2-201 significantly inhibits OXPHOS complex I as determined by its inhibition of oxidation of NADH to NAD+ in the NAD/NADH assay (IC₅₀ = 312 nM)^[1].
DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC₅₀ values of 0.4 μM and 0.6 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2749554-00-3
分子量 432.55
分子式 C₁₈H₂₈N₂O₆S₂
SMILES

O=S(N1C[C@@H](CCC1)C(OCC)=O)(C2=CC=C(C=C2)S(N(CC)CC)(=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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2025 Apr 11.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ding Xue, et al. Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors.J Med Chem. 2022 Jan 13;65(1):343-368. https://pubmed.ncbi.nlm.nih.gov/34982568/

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DX2-201

1 Cited Publications

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生物活性
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Publications (1)
純度とドキュメンテーション
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DX2-201

MedChemExpress（MCE）の使用を引用している文献 DX2-201

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

DX2-201 関連分類

製品番号: HY-145303