Dynamin IN-3
Dynamin IN-3 is an inhibitor of dynamin I. Dynamin IN-3 inhibits the GTPase activity of dynamin I, with an IC50 of 3.3 μM (based on sheep dynamin I)—and blocks clathrin-mediated endocytosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C27H38N4O2
- 分子量:450.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Dynamin I 3.3 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | IC50 |
4.3 μM
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Inhibition of clathrin-mediated endocytosis in human U2OS cells assessed by transferrin uptake assay.
Inhibition of clathrin-mediated endocytosis in human U2OS cells assessed by transferrin uptake assay.
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42721549 |
体外実験
Dynamin IN-3 (compound 97) (4.3 μM) inhibits clathrin-mediated endocytosis in U2OS cells with an IC50 of 4.3 μM[1].
Dynamin IN-3 (3-20 µM) inhibits CME in U2OS cells, with 3 and 20 µM reducing transferrin uptake and 20 µM producing near-complete loss of transferrin signal[1].
Dynamin IN-3 (30 mM stock; 30 min) inhibits native sheep brain dynamin I GTPase with an IC50 of 3.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 450.62
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分子式 C27H38N4O2
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SMILES
O=C(NCCCCCCCC)/C(C#N)=C/C1=CN(CCCN(C)C)C=C1C2=CC=CC(O)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dynamin IN-3 関連分類
HY-189875 関連分類
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