Eribaxaban
Based on 1 Customer Validation
Eribaxaban (PD-0348292) is an orally active and selective FXa inhibitor with a Ki value of 0.32 nM. Eribaxaban reduces thrombus formation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.52%
- CAS 番号: 536748-46-6
- 分子式: C24H22ClFN4O4
- 分子量:484.91
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Rivaroxaban (Standard)Factor Xa Inhibitor
生物活性
製品説明
IC50 & Target
Ki: 0.32 nM (FXa)[1]
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-month-old, pre-estrus, female pigs[2]
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Dosage:0.4, 0.9, 4.3 mg/kg
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Administration:P.o.; four hours prior to thrombus induction
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Result:Significantly reducted carotid platelet deposition, chamber platelet deposition.
化学情報
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CAS 番号 536748-46-6
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性状 Solid
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分子量 484.91
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分子式 C24H22ClFN4O4
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Color Light yellow to yellow
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SMILES
O=C(NC(C=C1)=CC=C1Cl)N2[C@H](C[C@@H](OC)C2)C(NC3=CC=C(C=C3F)N(C=CC=C4)C4=O)=O
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別名
PD-0348292
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (257.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Eriksson BI, et al. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clin Pharmacokinet. 2009;48(1):1-22. [Content Brief]
[2]. Karnicki K, et al. Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis. Thromb Haemost. 2008 Apr;99(4):759-66. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0622 mL | 10.3112 mL | 20.6224 mL | 51.5560 mL |
| 5 mM | 0.4124 mL | 2.0622 mL | 4.1245 mL | 10.3112 mL | |
| 10 mM | 0.2062 mL | 1.0311 mL | 2.0622 mL | 5.1556 mL | |
| 15 mM | 0.1375 mL | 0.6874 mL | 1.3748 mL | 3.4371 mL | |
| 20 mM | 0.1031 mL | 0.5156 mL | 1.0311 mL | 2.5778 mL | |
| 25 mM | 0.0825 mL | 0.4124 mL | 0.8249 mL | 2.0622 mL | |
| 30 mM | 0.0687 mL | 0.3437 mL | 0.6874 mL | 1.7185 mL | |
| 40 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2889 mL | |
| 50 mM | 0.0412 mL | 0.2062 mL | 0.4124 mL | 1.0311 mL | |
| 60 mM | 0.0344 mL | 0.1719 mL | 0.3437 mL | 0.8593 mL | |
| 80 mM | 0.0258 mL | 0.1289 mL | 0.2578 mL | 0.6444 mL | |
| 100 mM | 0.0206 mL | 0.1031 mL | 0.2062 mL | 0.5156 mL |
Eribaxaban 関連分類
HY-10267 関連分類
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