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製品番号: HY-122595

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EZH2-IN-1

EZH2-IN-1 (compound 3) is a selective and SAM-competitive EZH2 and EZH1 inhibitor with an IC₅₀s of 32 nM, 197 nM and 213 nM for EZH2wt, EZH2 Y641N mutant and EZH1, respectively. EZH2-IN-1 reduces bulk H3K27me3 and H3K27me2 levels. EZH2-IN-1 has the potential for diffuse large B cell lymphoma research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1377997-28-8
分子式: C₂₇H₂₈ClN₅O₂
分子量:490.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

EZH2-IN-1 構造式

CAS 番号: 1377997-28-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	7 μM Compound: 23	Inhibition of EZH2 in human HeLa cells assessed as reduction of H3K27me3 and H3K27me2 level after 96 hrs by ELISA method Inhibition of EZH2 in human HeLa cells assessed as reduction of H3K27me3 and H3K27me2 level after 96 hrs by ELISA method	[PMID: 25406853]
KARPAS-422	GI₅₀	13.2 μM Compound: 44	Growth inhibition of human KARPAS422 cells after 14 days by Cell-Titer luminescence assay Growth inhibition of human KARPAS422 cells after 14 days by Cell-Titer luminescence assay	[PMID: 24900844]
KARPAS-422	GI₅₀	23 μM Compound: 44	Growth inhibition of human KARPAS422 cells after 10 days by Cell-Titer luminescence assay Growth inhibition of human KARPAS422 cells after 10 days by Cell-Titer luminescence assay	[PMID: 24900844]
KARPAS-422	GI₅₀	24.8 μM Compound: 44	Growth inhibition of human KARPAS422 cells after 7 days by Cell-Titer luminescence assay Growth inhibition of human KARPAS422 cells after 7 days by Cell-Titer luminescence assay	[PMID: 24900844]
KARPAS-422	GI₅₀	70 μM Compound: 44	Growth inhibition of human KARPAS422 cells after 4 days by Cell-Titer luminescence assay Growth inhibition of human KARPAS422 cells after 4 days by Cell-Titer luminescence assay	[PMID: 24900844]
KARPAS-422	GI₅₀	9.1 μM Compound: 44	Growth inhibition of human KARPAS422 cells after 17 days by Cell-Titer luminescence assay Growth inhibition of human KARPAS422 cells after 17 days by Cell-Titer luminescence assay	[PMID: 24900844]

化学情報

CAS 番号 1377997-28-8
分子量 490.00
分子式 C₂₇H₂₈ClN₅O₂
SMILES

O=C(NC1CC(C)(C)NC(C)(C)C1)C2=CC=C(OC3=CC=CC(C4=CC=NN=C4)=C3C#N)C(Cl)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Shivani Garapaty-Rao, et al.Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth. Chem Biol. 2013 Nov 21;20(11):1329-39. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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