F-17
F-17 is a potential inhibitor of virulence factor. F-17 shows very significant inhibitory effect on biofilm, elastase, pyocyanin, and swarming motility. F-17 also shows a good binding effect on LasR and PqsR. F-17 has no obvious cytotoxicity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1572464-22-2
- 分子式: C17H15BrO4
- 分子量:363.20
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
35.4 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| ECa-109 cell line | IC50 |
40.3 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay
Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| HeLa | IC50 |
56.8 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| MCF7 | IC50 |
28.2 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 1572464-22-2
-
分子量 363.20
-
分子式 C17H15BrO4
-
SMILES
O=C(OCCC1=CC=C(Br)C=C1)/C=C/C2=CC=C(O)C(O)=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)