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製品番号: HY-D2318

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Flipper-TR 5

Flipper-TR 5 is a Flipper probe containing a terminal carboxylate for retention on the plasma membrane. Flipper-TR 5 selectively labels the cytoplasmic membrane, and exhibits excellent mechanical sensitivity, negligible cytotoxicity and controllable phototoxicity.

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CAS 番号: 2081888-04-0
分子式: C₂₇H₂₀N₄O₅S₆
分子量:672.86

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Flipper-TR 5 構造式

CAS 番号: 2081888-04-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Flipper-TR 5 exhibits ground-state planarization-dependent fluorescence and spectral shifts in solution and lipid bilayer membranes, with increasing red shifts, fluorescence intensity, and vibrational finestructure in increasingly ordered membranes^[1].
Flipper-TR 5 shows longer fluorescence lifetimes in more ordered Lo lipid bilayer membranes compared to Ld membranes in GUVs, with non-selective partitioning but phase-dependent fluorescence intensity^[1].
Flipper-TR 5 reports on membrane tension and organization in living cells, with fluorescence lifetimes that shift in response to hyperosmotic stress in plasma membranes, ER, and Golgi apparatus, and baseline lifetime differences driven by membrane order^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Flipper-TR 5 (direct application to embryo system) reliably reports membrane tension changes linked to ASPP2-dependent F-actin organization in mechanically stressed mouse embryo apical junctions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2081888-04-0
分子量 672.86
分子式 C₂₇H₂₀N₄O₅S₆
SMILES

CC1=C(C#N)SC(C2=C3C(C)=C(C4=C(C)C(SC5=C6SC(COCC7=CN(CC(O)=O)N=N7)=C5C)=C6S4)S2)=C1S3(=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen XX, et al. Fluorescent Flippers: Small-Molecule Probes to Image Membrane Tension in Living Systems. Angew Chem Int Ed Engl. 2023;62(20):e202217868. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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