Fludarabine-Cl
Based on 2 publication(s) in Google Scholar
Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.86%
- CAS 番号: 2734853-80-4
- 分子式: C10H11ClFN5O3
- 分子量:303.68
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Fludarabine-Cl
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生物活性
製品説明
IC50 & Target
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ADAR1 0.87 μM (IC50) |
体外実験
Fludarabine-Cl inhibits tumor cell proliferation, and has only a weak inhibitory effect on normal RWPE1 and HEK293 cells. The IC50 for MDA-MB-23, RPMI822, HL60 and K562 is 0.383, 0.149, 0.544 and 0.609 μM[1].
Fludarabine-Cl binds to ADAR1 protein with a KD of 7.24 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Fludarabine-Cl (10-20 mg/kg, intraperitoneal injection, twice a day, for 29 days) inhibits tumor proliferation in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[1]
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Dosage:104.9, 131.1, 163.8, 204.8, 256, 320, 400 mg/kg; twice a day; one day
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Administration:Intraperitoneal injection (i.p.)
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Result:Was somewhat toxic and could cause death in mice at higher doses, but no abnormality in organs.
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Animal Model:BALB/c mice induced by Du-145[1]
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Dosage:10, 20 mg/kg; twice a day; 29 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth and had no effect on mouse body weight.
化学情報
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CAS 番号 2734853-80-4
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性状 Solid
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分子量 303.68
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分子式 C10H11ClFN5O3
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Color White to off-white
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SMILES
NC1=NC(F)=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CCl)O3
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別名
ZYS-1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
Targeting ADAR1 lactylation activates innate immune and overcomes chemoresistance in ovarian cancer. [Abstract]2026 May 25. PMID: 42185630 -
溶剤 & 溶解度
体外:
DMSO : 12.5 mg/mL (41.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (6.59 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2929 mL | 16.4647 mL | 32.9294 mL | 82.3235 mL |
| 5 mM | 0.6586 mL | 3.2929 mL | 6.5859 mL | 16.4647 mL | |
| 10 mM | 0.3293 mL | 1.6465 mL | 3.2929 mL | 8.2324 mL | |
| 15 mM | 0.2195 mL | 1.0976 mL | 2.1953 mL | 5.4882 mL | |
| 20 mM | 0.1646 mL | 0.8232 mL | 1.6465 mL | 4.1162 mL | |
| 25 mM | 0.1317 mL | 0.6586 mL | 1.3172 mL | 3.2929 mL | |
| 30 mM | 0.1098 mL | 0.5488 mL | 1.0976 mL | 2.7441 mL | |
| 40 mM | 0.0823 mL | 0.4116 mL | 0.8232 mL | 2.0581 mL |
Fludarabine-Cl 関連分類
HY-145443 関連分類
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