G43
Based on 1 Customer Validation
G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.76%
- CAS 番号: 690693-02-8
- 分子式: C16H11N3O4S
- 分子量:341.34
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
G43 (16 h) inhibits more than 85% of S. mutans biofilm at 12.5 μM[1].
G43 (25 μM, 24 h) reduces the glucan production by the glucosyltransferase (Gtfs), and consistently inhibits the activity of both GtfB and GtfC with 80% inhibition of both enzymes[1].
G43 (up to 25 μM, 24 h) shows no significant difference on expression of gtfs (gtfB, gtfC and gtfD) in S. mutans. UA159 cells[1].
G43 (50 μM, 24-48 h) reduces the biofilm formation by decreasing the production of Water-insoluble extracellular polysaccharide in wild-type S. mutans[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. mutans. UA159 cells
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Concentration:3.125, 6.25, 12, 25 μM
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Incubation Time:24 h
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Result:Showed no significant difference on expression of gtfs (gtfB, gtfC and gtfD).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:The rat model of dental caries infected with S. mutans UA159[1]
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Dosage:100 µM twice daily for 4 weeks
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Administration:Topically administration
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Result:Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study.
化学情報
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CAS 番号 690693-02-8
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性状 Solid
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分子量 341.34
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分子式 C16H11N3O4S
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Color White to off-white
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SMILES
O=C(C1=CC2=C(S1)C=CC([N+]([O-])=O)=C2)NC3=CC=CC=C3C(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 20 mg/mL (58.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zhang Q, et al. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci Rep. 2017;7(1):5974. [Content Brief]
[2]. Scaffa PMC, et al. The potential use of glycosyl-transferase inhibitors for targeted reduction of S. mutans biofilms in dental materials. Sci Rep. 2023;13(1):11889. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9296 mL | 14.6482 mL | 29.2963 mL | 73.2408 mL |
| 5 mM | 0.5859 mL | 2.9296 mL | 5.8593 mL | 14.6482 mL | |
| 10 mM | 0.2930 mL | 1.4648 mL | 2.9296 mL | 7.3241 mL | |
| 15 mM | 0.1953 mL | 0.9765 mL | 1.9531 mL | 4.8827 mL | |
| 20 mM | 0.1465 mL | 0.7324 mL | 1.4648 mL | 3.6620 mL | |
| 25 mM | 0.1172 mL | 0.5859 mL | 1.1719 mL | 2.9296 mL | |
| 30 mM | 0.0977 mL | 0.4883 mL | 0.9765 mL | 2.4414 mL | |
| 40 mM | 0.0732 mL | 0.3662 mL | 0.7324 mL | 1.8310 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5859 mL | 1.4648 mL |
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