Galegenimab
Based on 1 Customer Validation
Galegenimab (FHTR 2163) is a humanized monoclonal antibody Fab fragment targeting the HtrA1 trimer. Galegenimab is used in research on age-related macular degeneration (AMD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 2403683-24-7
- 分子量:47.71 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Fab IgG1 kappa
Human
HTRA1
As a humanized monoclonal antibody Fab fragment targeting HtrA1, Galegenimab binds to each subunit of the HtrA1 trimer with three independent Fabs to form a macromolecular complex, thereby inhibiting the protease activity of HtrA1 and blocking its proteolytic effect on extracellular matrix protein substrates such as biglycan[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Fab-G1-kappa
ELISA, FACS, Functional assay
化学情報
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CAS 番号 2403683-24-7
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性状 Liquid
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分子量 47.71 kDa
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Color Colorless to light yellow
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SMILES
[Galegenimab]
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別名
FHTR 2163; RG 6147; RO 7171009
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Jonathan B Lin, et al. Neuroprotection for Age-Related Macular Degeneration. Ophthalmol Sci. 2022 Jul 5;2(4):100192. [Content Brief]
[2]. Eichenbaum DA, et al. Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Am J Ophthalmol. 2025 Jul;275:14-26. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Galegenimab 関連分類
HY-P99629 関連分類
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