GCC-1
GCC-1 is a glycolipid. GCC-1 binds to CD1d to form a glycolipid-CD1d complex, which is presented to cellular TCR, thereby activating cells in a CD1d-dependent manner. GCC-1 induces Th1-biased cellular activation and IFN-γ production. GCC-1 can be used for research on colon adenocarcinoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C52H93NO10
- 分子量:892.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
CD1d |
体外実験
GCC-1 (100 nM; 2-24 h) is more efficiently presented and persists longer on the surface of DC2.4 cells than αGalCer via CD1d-mediated antigen presentation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
GCC-1 (1 nmol; i.v.; on days 3 and 10) induces potent antitumor activity, reducing tumor volume to approximately 1000 mm3 and prolonging survival[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[1]
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Dosage:1 nmol
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Administration:i.v.; on days 3 and 10
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Result:Reduced average tumor volume to approximately 1000 mm3 on day 30, whereas control groups exhibited tumor volumes close to 2000 mm3.
Significantly prolonged survival relative to αGalCer.
化学情報
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分子量 892.30
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分子式 C52H93NO10
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SMILES
OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@@H]1OC[C@H](NC(CC2=CC=C(OCC3CCCCCCCCCCCCCCCCCC3)C=C2)=O)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GCC-1 関連分類
HY-189458 関連分類
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