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Gemtuzumab

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Based on 1 Customer Validation

Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

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  • 純度: 99.54%
  • CAS 番号: 2924764-21-4
  • 分子量:145.22 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Gemtuzumab
  • Experimental Validation Results for Gemtuzumab
  • Experimental Validation Results for Gemtuzumab
  • Gemtuzumab Chemical Structure
    Gemtuzumab 構造式
CAS 番号: 2924764-21-4
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To place orders, for customer services and technical support, please contact:

609-228-6898
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Siglec-3/CD33 Protein, Human can bind Gemtuzumab. The EC50 for this effect is 4.328 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 THP-1 cells with Gemtuzumab (HY-P99971, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa, Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Gemtuzumab Chemical Structure
    1/16
  • Gemtuzumab
  • Immobilized Siglec-3/CD33 Protein, Human can bind Gemtuzumab. The EC50 for this effect is 4.328 ng/mL.
  • Flow cytometric analysis of 1.5X106 THP-1 cells with Gemtuzumab (HY-P99971, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa, Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).