MED16 - mediator complex subunit 16 Gene

Also Known as DRIP92; THRAP5; TRAP95

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10025

About MED16

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:867,963-893,187 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in ovary (RPKM 10.5), kidney (RPKM 10.1) and 25 other tissues.

Summary

Enables Thyroid Hormone Receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]

MED16 Products (1)

mRNA	Protein	Name
NM_005481.3	NP_005472.2	mediator of RNA polymerase II transcription subunit 16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24882805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED16 Protein Structure

WD40

Med16

0
200
400
600
800
877 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 16	thyroid hormone receptor-associated protein 5

MED16 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MED16	Q9Y2X0	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	24882805
Intra	MED16	Q9Y2X0	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED16	Q9Y2X0	MED24	Homo sapiens	O75448	Anti Tag CoIP	24882805
Intra	MED16	Q9Y2X0	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

MED16 抗体

製品番号	製品名	アプリケーション	反応性
HY-P89946	TRAP95 Antibody (YA9290)	WB, ICC/IF, IF-Tissue, IP	human

Diseases	Alias
Mixed Fibrolamellar Hepatocellular Carcinoma
Lipodystrophy, Congenital Generalized, Type 3	Congenital Generalized Lipodystrophy Type 3 CGL3 Bscl3 Berardinelli-Seip Congenital Lipodystrophy Type 3 Berardinelli-Seip Congenital Lipodystrophy, Type 3 Lipodystrophy, Berardinelli-Seip Congenital, Type 3 Type 3 Berardinelli-Seip Congenital Lipodystrophy Congenital Generalized Lipodystrophy 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS08287	MED16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	MED16	VGNC	VGNC:31354
Canis familiaris	MED16	VGNC	VGNC:43126
Mus musculus	MED16	MGD	MGI:2158394
Felis catus	MED16	VGNC	VGNC:80624
Rattus norvegicus	MED16	RGD	RGD:1308001
Macaca mulatta	MED16	VGNC	VGNC:74525
Others	MED16	NCBI