NEK6 - NIMA related kinase 6 Gene
Also Known as SID6-1512
生物種: Homo sapiens
遺伝子タイプ: protein coding
遺伝子ID: 10783
About NEK6
Cytogenetic location: 9q33.3
Genomic coordinates (GRCh38): 9:124,257,606-124,353,307 (from NCBI)
This gene has 15 transcripts (splice variants), 180 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues.
Summary
The protein encoded by this gene is a kinase required for progression through the metaphase portion of Mitosis. Inhibition of the encoded protein can lead to Apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
NEK6 Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145001.3 | NP_001138473.1 | serine/threonine-protein kinase Nek6 isoform 1 |
| NM_001166167.2 | NP_001159639.1 | serine/threonine-protein kinase Nek6 isoform 3 |
| NM_001166168.2 | NP_001159640.1 | serine/threonine-protein kinase Nek6 isoform 2 |
| NM_001166169.2 | NP_001159641.1 | serine/threonine-protein kinase Nek6 isoform 4 |
| NM_001166170.2 | NP_001159642.1 | serine/threonine-protein kinase Nek6 isoform 2 |
| NM_001166171.2 | NP_001159643.1 | serine/threonine-protein kinase Nek6 isoform 1 |
| NM_014397.6 | NP_055212.2 | serine/threonine-protein kinase Nek6 isoform 2 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables ATP binding |
IDA
IDA: Inferred from direct assay
|
14563848 | GOA |
| enables DNA-binding transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
20873783 | GOA |
| enables kinesin binding |
IPI
IPI: Inferred from physical interaction
|
19001501 | GOA |
| enables magnesium ion binding |
IDA
IDA: Inferred from direct assay
|
14563848 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16476580 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
19001501 | GOA |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
11516946 | GOA |
| enables transcription corepressor binding |
IPI
IPI: Inferred from physical interaction
|
20873783 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
20873783 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in chromosome segregation |
IDA
IDA: Inferred from direct assay
|
14563848 | GOA |
| involved in peptidyl-serine phosphorylation |
IDA
IDA: Inferred from direct assay
|
19001501 | GOA |
| involved in protein autophosphorylation |
IDA
IDA: Inferred from direct assay
|
14563848 | GOA |
| involved in protein phosphorylation |
IDA
IDA: Inferred from direct assay
|
12840024 | GOA |
| involved in regulation of mitotic metaphase/anaphase transition |
IDA
IDA: Inferred from direct assay
|
14563848 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| colocalizes with centrosome |
IDA
IDA: Inferred from direct assay
|
20873783 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
12054534 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
12054534 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
20873783 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
NEK6 Protein Structure
Pkinase
Pkinase: Protein kinase domain (45 - 298)
- 0
- 100
- 200
- 313 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein kinase Nek6 |
|
NEK6 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
NEK6 | Q9HC98 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | TASOR2 | Homo sapiens | Q5VWN6-2 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | TASOR2 | Homo sapiens | Q5VWN6-2 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | NECAB2 | Homo sapiens | Q7Z6G3-2 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | NEK9 | Homo sapiens | Q8TD19 | 32707033 | |
|
Intra
|
NEK6 | Q9HC98 | NEK9 | Homo sapiens | Q8TD19 | 17353931 | |
|
Intra
|
NEK6 | Q9HC98 | NEK9 | Homo sapiens | Q8TD19 | 33961781 | |
|
Intra
|
NEK6 | Q9HC98 | NEK9 | Homo sapiens | Q8TD19 | 28514442 | |
|
Intra
|
NEK6 | Q9HC98 | XIAP | Homo sapiens | P98170 | 31515488 | |
|
Intra
|
NEK6 | Q9HC98 | XIAP | Homo sapiens | P98170 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | TNK2 | Homo sapiens | Q07912 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | PIN1 | Homo sapiens | Q13526 | 16476580 | |
|
Intra
|
NEK6 | Q9HC98 | PIN1 | Homo sapiens | Q13526 | 16476580 | |
|
Intra
|
NEK6 | Q9HC98 | PIN1 | Homo sapiens | Q13526 | 16476580 | |
|
Intra
|
NEK6 | Q9HC98 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | LNX1 | Homo sapiens | Q8TBB1 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | LNX1 | Homo sapiens | Q8TBB1 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | LZTS2 | Homo sapiens | Q9BRK4 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | HSD17B14 | Homo sapiens | Q9BPX1 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | HSD17B14 | Homo sapiens | Q9BPX1 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IKZF1 | Homo sapiens | Q13422 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IKZF1 | Homo sapiens | Q13422 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IKZF1 | Homo sapiens | Q13422 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IKZF3 | Homo sapiens | Q9UKT9 | 31515488 | |
|
Intra
|
NEK6 | Q9HC98 | IKZF3 | Homo sapiens | Q9UKT9 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IKZF3 | Homo sapiens | Q9UKT9 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IHO1 | Homo sapiens | Q8IYA8 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | IHO1 | Homo sapiens | Q8IYA8 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
NEK6 | Q9HC98 | KRT31 | Homo sapiens | Q15323 | 25416956 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
NEK6 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P82651 | NEK6 Antibody (YA2396) | WB, IP | Human, Mouse, Rat |
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Macaca mulatta | NEK6 | VGNC | VGNC:75311 |
| Bos taurus | NEK6 | VGNC | VGNC:31997 |
| Felis catus | NEK6 | VGNC | VGNC:68459 |
| Canis familiaris | NEK6 | VGNC | VGNC:43733 |
| Mus musculus | NEK6 | MGD | MGI:1891638 |
| Rattus norvegicus | NEK6 | RGD | RGD:727779 |
| Others | NEK6 | NCBI |
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