Brca2 - breast cancer 2, early onset Gene

Also Known as Fancd1; RAB163

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 12190

Summary

Predicted to enable several functions, including gamma-tubulin binding activity; Histone Acetyltransferase activity; and protein C-terminus binding activity. Involved in several processes, including establishment of protein localization to telomere; male meiosis I; and telomere maintenance via recombination. Acts upstream of or within several processes, including DNA metabolic process; gamete generation; and signal transduction by p53 class mediator. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Used to study Fanconi anemia complementation group D1 and breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain Cancer (multiple); hereditary breast ovarian Cancer syndrome; melanoma (multiple); and reproductive organ Cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]

Brca2 Products (2)

mRNA Protein Name
NM_001081001.2 NP_001074470.1 breast cancer type 2 susceptibility protein homolog
NM_009765.3 NP_033895.2 breast cancer type 2 susceptibility protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
9126738 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA damage response IDA
IDA: Inferred from direct assay
12410562 MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: Inferred from mutant phenotype
8738145 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
17476307 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
9171368 MGI
acts upstream of or within cellular senescence IMP
IMP: Inferred from mutant phenotype
9699678 MGI
acts upstream of or within chordate embryonic development IMP
IMP: Inferred from mutant phenotype
9171368 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
9660919 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
9398843 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
15485900 MGI
involved in establishment of protein localization to telomere IDA
IDA: Inferred from direct assay
21076401 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
9398843 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
16859999 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
16859999 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
9171369 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: Inferred from genetic interaction
17476307 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
IGI: Inferred from genetic interaction
17476307 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15735671 MGI
involved in male meiosis I IDA
IDA: Inferred from direct assay
32345962 MGI
acts upstream of or within male meiosis I IMP
IMP: Inferred from mutant phenotype
14660434 MGI
acts upstream of or within oocyte maturation IMP
IMP: Inferred from mutant phenotype
14660434 MGI
acts upstream of or within positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
9660919 MGI
acts upstream of or within regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
15375219 MGI
acts upstream of or within replication fork processing IMP
IMP: Inferred from mutant phenotype
14681210 MGI
acts upstream of or within response to UV-C IMP
IMP: Inferred from mutant phenotype
9660919 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
9398843 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
9126738 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
9398843 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9398843 MGI
involved in telomere maintenance via recombination IGI
IGI: Inferred from genetic interaction
21076401 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in chromosome IDA
IDA: Inferred from direct assay
30760716 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11172592 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11172592 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breast cancer type 2 susceptibility protein homolog

  • fanconi anemia group D1 protein homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-115552 Simmiparib Inhibitor 99.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (36)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-124691 D-I03 Inhibitor 99.70% Unkown
HY-151462 RP-6685 Inhibitor 99.96% Unkown
HY-150147 CAM833 99.83% Unkown
HY-170844 MU147 Inhibitor 99.35% Unkown
HY-122639 ZINC05007751 99.33% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-148183 Homologous recombination-IN-1 Inhibitor 98.65% Unkown
HY-40041 (R)-1-Boc-3-methyl-piperazine 99.86% Unkown
HY-161431 RTx-152 99.71% Unkown
HY-168993 BRCA2-IN-2 Inhibitor 97.30% Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-170845 MU1409 Inhibitor 98.52% Unkown
HY-135782A iso-ADP ribose TEA 99.97% Unkown
HY-181557 SY-589 98.50% Unkown
HY-135782 iso-ADP ribose / Unkown
HY-153338 C791-0064 99.15% Unkown
HY-158346 RP-2119 Inhibitor 99.94% Unkown
HY-RS01594 BRCA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179219S RTx-303 Inhibitor / Unkown
HY-10617AS1 Rucaparib-d3 Inhibitor / Unkown
HY-122583 D-G23 Inhibitor / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-150958 RAD51-IN-8 / Unkown
HY-153755 ART6043 Inhibitor / Unkown
HY-155766 PARP1-IN-14 / Unkown
HY-163816 Antiproliferative agent-53-d3 Inhibitor / Unkown
HY-168094 PARP1-IN-30 Inhibitor / Unkown
HY-173151 BRCA2-IN-1 Inhibitor / Unkown
HY-173345 BRCA2-RAD51-IN-2 Inhibitor / Unkown
HY-179413 Polθ-IN-9 Inhibitor / Unkown
HY-182322 POLQ-IN-1 Inhibitor / Unkown
HY-P10516 BRC4 peptide / Unkown
HY-162104 BRCA2-RAD51-IN-1 Inhibitor / Unkown
HY-181561 BRCA2-RAD51-IN-3 Inhibitor / Unkown
HY-RS16825 Brca2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23267 Brca2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Brca2 NCBI NCBI:675