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Cd74 - CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Gene

Also Known as Ii; CLIP; DHLAG; HLADG; Ia-GAMMA

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 16149

Summary

Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and Thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd74 Products (2)

mRNA	Protein	Name
NM_001042605.1	NP_001036070.1	H-2 class II histocompatibility antigen gamma chain isoform 1
NM_010545.3	NP_034675.1	H-2 class II histocompatibility antigen gamma chain isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables MHC class II protein binding	IPI IPI: Inferred from physical interaction	7985028	MGI
contributes to cytokine binding	IDA IDA: Inferred from direct assay	18056708	MGI
enables cytokine receptor activity	IMP IMP: Inferred from mutant phenotype	12782713	MGI
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	18003616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7985028	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within antigen processing and presentation	IDA IDA: Inferred from direct assay	3864916	MGI
acts upstream of or within antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	9432982	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	7679955	MGI
acts upstream of or within chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	7985028	MGI
acts upstream of or within chaperone cofactor-dependent protein refolding	IMP IMP: Inferred from mutant phenotype	7679955	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	8098731	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	7679955	MGI
acts upstream of or within intracellular protein transport	IDA IDA: Inferred from direct assay	11754812	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in macrophage migration inhibitory factor signaling pathway	IDA IDA: Inferred from direct assay	19413900	MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17045821	MGI
acts upstream of or within negative regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17045821	MGI
involved in negative regulation of mature B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18056708	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	12782713	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	19413900	MGI
involved in positive regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12782713	MGI
involved in positive regulation of dendritic cell antigen processing and presentation	IDA IDA: Inferred from direct assay	18003616	MGI
involved in positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	19413900	MGI
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	19413900	MGI
involved in positive regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	11823488	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	11483509	MGI
acts upstream of or within protein-containing complex assembly	IDA IDA: Inferred from direct assay	7985028	MGI
involved in response to type II interferon	IDA IDA: Inferred from direct assay	32855215	MGI

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11854359	MGI
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	7985028	MGI
part of NOS2-CD74 complex	IDA IDA: Inferred from direct assay	18003616	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	11854359	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7679955	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12417635	MGI
located in late endosome	IDA IDA: Inferred from direct assay	11483509	MGI
located in lysosome	IDA IDA: Inferred from direct assay	11483509	MGI
part of macrophage migration inhibitory factor receptor complex	IDA IDA: Inferred from direct assay	12782713	MGI
located in multivesicular body	IDA IDA: Inferred from direct assay	11854359	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8294875	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	8098731	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
H-2 class II histocompatibility antigen gamma chain	HLA-DR-GAMMA Ia-associated invariant chain MHC class II-associated invariant chain class II-associated invariant chain peptide dinucleotide microsatellite histocompatibility: class II antigens, gamma chain of ia antigen-associated invariant chain i

Recombinant Cd74 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P72710	CD74 Protein, Mouse (160a.a, HEK293, His)	P04441-2 (Q56-L215)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78262	CD74 Protein, Mouse (224a.a, HEK293, His)	P04441-1 (Q56-L279)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Phase
HY-P99731	Milatuzumab	Inhibitor	99.39%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P1826	CLIP (86-100)		98.39%	Unkown
HY-P11303	PADRE peptide	Ligand	98.28%	Unkown
HY-103333	Arvanil	Inhibitor	99.1%	Unkown
HY-N2245	Schisandrone	Inhibitor	99.78%	Unkown
HY-107101	(5R)-5-Hydroxytriptolide	Inhibitor	99.67%	Unkown
HY-128356	SPL-410	Inhibitor	99.38%	Unkown
HY-D3334	PE-CF594		/	Unkown

阻害性抗体 (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P990728	Bezetabart	Inhibitor	99.00%	Unkown
HY-P991837	Anti-HLA-DP Antibody (B7/21)	Inhibitor	/	Unkown
HY-P991844	Anti-HLA-DQ Antibody (1a3)	Inhibitor	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Cd74	NCBI	NCBI:972