ECM1 - extracellular matrix protein 1 Gene

Also Known as URBWD

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 1893

About ECM1

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,508,109-150,513,789 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and is associated with 4 phenotypes. Biased expression in esophagus (RPKM 332.0), gall bladder (RPKM 47.3) and 3 other tissues.

Summary

This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

ECM1 Products (3)

mRNA Protein Name
NM_001202858.2 NP_001189787.1 extracellular matrix protein 1 isoform 3 precursor
NM_004425.4 NP_004416.2 extracellular matrix protein 1 isoform 1 precursor
NM_022664.3 NP_073155.2 extracellular matrix protein 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protease binding IPI
IPI: Inferred from physical interaction
16512877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12604605 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of bone mineralization IDA
IDA: Inferred from direct assay
11165938 GOA
involved in negative regulation of peptidase activity IDA
IDA: Inferred from direct assay
16512877 GOA
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
11292659 GOA
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
11292659 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
20870722 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECM1 Protein Structure

ECM1

ECM1: Extracellular matrix protein 1 (ECM1) (1 - 540)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 540 a.a.
Protein Preferred Names Protein Names

extracellular matrix protein 1

  • secretory component p85

ECM1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ECM1 Q16610 LCE2A Homo sapiens Q5TA79
Validated Y2H
32296183
Intra
ECM1 Q16610 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
ECM1 Q16610 KRTAP5-3 Homo sapiens Q6L8H2
Validated Y2H
32296183
Intra
ECM1 Q16610 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
ECM1 Q16610 SAMD11 Homo sapiens Q96NU1
Validated Y2H
32296183
Intra
ECM1 Q16610 A1CF Homo sapiens Q9NQ94
Validated Y2H
32296183
Intra
ECM1 Q16610 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
ECM1 Q16610 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
ECM1 Q16610 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
ECM1 Q16610 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
ECM1 Q16610 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
ECM1 Q16610 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra
ECM1 Q16610 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ECM1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83042 Extracellular Matrix Protein 1 Antibody (YA2787) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Rat
HY-P83042A Extracellular Matrix Protein 1 Antibody (YA2787)(PBS only) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Rat

関連疾患

Diseases Alias
Lipoid Proteinosis Of Urbach And Wiethe

  • Lipoid Proteinosis

  • Urbach-Wiethe Disease

  • Hyalinosis Cutis Et Mucosae

  • Lipid Proteinosis

  • Lipoproteinosis

  • Urbach Wiethe Disease

  • Lipoglycoproteinosis

  • Lipoidosis Cutis Et Mucosae

  • Lipoidproteinosis

  • Urbach-Wiethe Lipoid Proteinosis

  • Urbach-Wiethe Syndrome

  • LIP

  • Proteinosis Lipoid
Lichen Sclerosus Et Atrophicus

  • Lichen Sclerosus

  • LSA

  • Lichen Sclerosis

  • Lichen Sclerosis Et Atrophicus

  • Ls Et A - [Lichen Sclerosus Et Atrophicus]

  • Lichen Albus
Balanitis Xerotica Obliterans

  • Penile Lichen Sclerosus

  • Penile Leukoplakia
Urethral Syndrome

  • Urethral Disease

  • Urethral Diseases

  • Urethra Disease

  • Abnormality Of The Urethra

  • Urethral Disorders
Doyne Honeycomb Retinal Dystrophy

  • DHRD

  • Doyne Honeycomb Degeneration Of Retina

  • Dhd

  • Malattia Leventinese

  • Ml

  • Mlvt

  • Dystrophy, Retinal, Doyne Honeycomb
Phimosis

  • Tight Foreskin

  • Tight Frenulum

  • Congenital Phimosis
Vulvar Dystrophy

  • Dystrophy Of Vulva
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Retinal Drusen
Brugada Syndrome 9

  • BRGDA9

  • Brugada Syndrome, Type 9
Balanitis
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04143 ECM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17452 Ecm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23908 Ecm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus ECM1 VGNC VGNC:61711
Rattus norvegicus ECM1 RGD RGD:620357
Bos taurus ECM1 VGNC VGNC:28311
Macaca mulatta ECM1 VGNC VGNC:72151
Mus musculus ECM1 MGD MGI:103060
Others ECM1 NCBI