Nectin2 - nectin cell adhesion molecule 2 Gene

Also Known as MPH; Pvr; Pvs; Cd112; Pvrl2; nectin-2

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 19294

Summary

Enables cell adhesion molecule binding activity and protein homodimerization activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid development. Located in cell-cell contact zone; plasma membrane; and zonula adherens. Is expressed in brain; cochlea; enamel organ; male reproductive system; and primitive collecting duct. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]

Nectin2 Products (2)

mRNA	Protein	Name
NM_001159724.1	NP_001153196.1	nectin-2 isoform 2 precursor
NM_008990.3	NP_033016.3	nectin-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	10225955	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22902367	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12759359	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12826663	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within acrosome assembly	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within cellular anatomical entity morphogenesis	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within establishment of mitochondrion localization	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	10733589	MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	12826663	MGI
acts upstream of or within sperm mitochondrion organization	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	10733589	MGI
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	10733589	MGI
acts upstream of or within spermatid nucleus differentiation	IMP IMP: Inferred from mutant phenotype	10733589	MGI

Cellular Component GO Annotation	Evidence	参考文献	由来
located in apical junction complex	IDA IDA: Inferred from direct assay	22512338	MGI
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23533177	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	15660130	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12826663	MGI
located in zonula adherens	IDA IDA: Inferred from direct assay	10225955	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nectin-2	herpes virus entry mediator B herpesvirus entry mediator B hveB mHveB murine herpes virus entry protein B murine herpesvirus entry protein B poliovirus receptor homolog poliovirus receptor-related 2 poliovirus receptor-related protein 2 polioviru

Recombinant Nectin2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7781	Nectin-2/CD112 Protein, Mouse (HEK293, His)	P32507 (Q32-G351)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS09175	NECTIN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18105	Nectin2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24579	Nectin2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P992428	NTX-1107C	Inhibitor	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Nectin2	NCBI	NCBI:5819