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TPGS2 - tubulin polyglutamylase complex subunit 2 Gene

Also Known as L17; PGs2; C18orf10; HMFN0601

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 25941

About TPGS2

This gene has 21 transcripts (splice variants) and 227 orthologues. Broad expression in testis (RPKM 16.4), brain (RPKM 5.6) and 24 other tissues.

Summary

This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

TPGS2 Products (10)

mRNA	Protein	Name
NM_001271949.2	NP_001258878.1	tubulin polyglutamylase complex subunit 2 isoform 2
NM_001271950.2	NP_001258879.1	tubulin polyglutamylase complex subunit 2 isoform 3
NM_001271951.2	NP_001258880.1	tubulin polyglutamylase complex subunit 2 isoform 4
NM_001271952.2	NP_001258881.1	tubulin polyglutamylase complex subunit 2 isoform 5
NM_001271953.2	NP_001258882.1	tubulin polyglutamylase complex subunit 2 isoform 6
NM_001271954.2	NP_001258883.1	tubulin polyglutamylase complex subunit 2 isoform 7
NM_001271955.2	NP_001258884.1	tubulin polyglutamylase complex subunit 2 isoform 8
NM_001271956.2	NP_001258885.1	tubulin polyglutamylase complex subunit 2 isoform 9
NM_001330572.2	NP_001317501.1	tubulin polyglutamylase complex subunit 2 isoform 10
NM_015476.4	NP_056291.2	tubulin polyglutamylase complex subunit 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tubulin polyglutamylase complex subunit 2	polyglutamylase subunit 2

TPGS2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	TPGS2	Q68CL5	OTP	Homo sapiens	Q5XKR4	Y2H Prey Pooling	32296183
Intra	TPGS2	Q68CL5	OTP	Homo sapiens	Q5XKR4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14931	TPGS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	TPGS2	VGNC	VGNC:36248
Mus musculus	TPGS2	MGD	MGI:1913898
Canis familiaris	TPGS2	VGNC	VGNC:47737
Rattus norvegicus	TPGS2	RGD	RGD:1310571
Macaca mulatta	TPGS2	VGNC	VGNC:79442
Others	TPGS2	NCBI