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APBB2 - amyloid beta precursor protein binding family B member 2 Gene

Also Known as FE65L; FE65L1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 323

About APBB2

Cytogenetic location: 4p14-p13 Genomic coordinates (GRCh38): 4:40,810,027-41,214,542 (from NCBI)

This gene has 30 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 13.0), thyroid (RPKM 11.7) and 24 other tissues.

Summary

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

APBB2 Products (9)

mRNA	Protein	Name
NM_001166050.2	NP_001159522.1	amyloid beta precursor protein binding family B member 2 isoform b
NM_001166051.2	NP_001159523.1	amyloid beta precursor protein binding family B member 2 isoform d
NM_001166052.2	NP_001159524.1	amyloid beta precursor protein binding family B member 2 isoform d
NM_001166053.1	NP_001159525.1	amyloid beta precursor protein binding family B member 2 isoform d
NM_001166054.1	NP_001159526.1	amyloid beta precursor protein binding family B member 2 isoform d
NM_001330656.2	NP_001317585.1	amyloid beta precursor protein binding family B member 2 isoform e
NM_001330658.2	NP_001317587.1	amyloid beta precursor protein binding family B member 2 isoform e
NM_004307.2	NP_004298.1	amyloid beta precursor protein binding family B member 2 isoform a
NM_173075.5	NP_775098.2	amyloid beta precursor protein binding family B member 2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	8855266	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of cell cycle phase transition	IDA IDA: Inferred from direct assay	12089154	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12089154	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14527950	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	14527950	GOA
located in early endosome	IDA IDA: Inferred from direct assay	14527950	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14527950	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12089154	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APBB2 Protein Structure

PID

0
200
400
600
758 a.a.

Protein Preferred Names	Protein Names
amyloid beta precursor protein binding family B member 2	Fe65-like 1

APBB2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	APBB2	Q92870	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	APBB2	Q92870	APP	Homo sapiens	P05067	Anti Tag CoIP	33961781
Intra	APBB2	Q92870	APP	Homo sapiens	P05067	Anti Tag CoIP	8855266
Intra	APBB2	Q92870	APP	Homo sapiens	P05067	Y2H	8855266
Intra	APBB2	Q92870	APLP2	Homo sapiens	Q06481	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS00806	APBB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	APBB2	VGNC	VGNC:26005
Felis catus	APBB2	VGNC	VGNC:67737
Mus musculus	APBB2	MGD	MGI:108405
Canis familiaris	APBB2	VGNC	VGNC:37979
Macaca mulatta	APBB2	VGNC	VGNC:69980
Rattus norvegicus	APBB2	RGD	RGD:1562438
Others	APBB2	NCBI