EIF6 - eukaryotic translation initiation factor 6 Gene

Also Known as CAB; EIF3A; eIF-6; p27BBP; ITGB4BP; b(2)gcn; p27(BBP)

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3692

About EIF6

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,278,906-35,284,772 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in esophagus (RPKM 55.8), duodenum (RPKM 45.2) and 25 other tissues.

Summary

Hemidesmosomes are structures which link the basal lamina to the intermediate filament Cytoskeleton. An important functional component of hemidesmosomes is the Integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament Cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

EIF6 Products (4)

mRNA Protein Name
NM_001267810.1 NP_001254739.1 eukaryotic translation initiation factor 6 isoform a
NM_002212.4 NP_002203.1 eukaryotic translation initiation factor 6 isoform a
NM_181466.3 NP_852131.1 eukaryotic translation initiation factor 6 isoform c
NM_181468.2 NP_852133.1 eukaryotic translation initiation factor 6 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
17507929 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
21536732 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in cytosolic ribosome assembly IMP
IMP: Inferred from mutant phenotype
21536732 GOA
involved in miRNA-mediated gene silencing by inhibition of translation IMP
IMP: Inferred from mutant phenotype
17507929 GOA
involved in miRNA-mediated post-transcriptional gene silencing IMP
IMP: Inferred from mutant phenotype
17507929 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF6 Protein Structure

eIF-6

eIF-6: eIF-6 family (4 - 204)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 6

  • B4 integrin interactor

EIF6 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
EIF6 P56537 MSRB3 Homo sapiens Q8IXL7-2
Validated Y2H
32296183
Intra
EIF6 P56537 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
EIF6 P56537 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
EIF6 P56537 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
EIF6 P56537 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
EIF6 P56537 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra
EIF6 P56537 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Cross
EIF6 P56537 Prkcb Mus musculus P68404
Protein Kinase Assay
21665150
Intra
EIF6 P56537 EIF2AK2 Homo sapiens P19525
Anti Tag CoIP
21903422
Intra
EIF6 P56537 NREP Homo sapiens Q16612
Anti Bait CoIP
22365962
Intra
EIF6 P56537 NREP Homo sapiens Q16612
Y2H
22365962
Cross: Cross-species interaction Intra: Intraspecies interaction

EIF6 抗体

製品番号 製品名 アプリケーション 反応性
HY-P87155 eIF-6 Antibody (YA6848) WB Human, Mouse, Rat

関連疾患

Diseases Alias
Shwachman-Diamond Syndrome 1

  • Shwachman-Diamond Syndrome

  • Shwachman Syndrome

  • Shwachman-Bodian-Diamond Syndrome

  • Sds

  • Pancreatic Insufficiency And Bone Marrow Dysfunction

  • Shwachman-Bodian Syndrome

  • SDS1

  • Lipomatosis Of Pancreas, Congenital

  • Congenital Lipomatosis Of Pancreas

  • Shwachman-Diamond Type Metaphyseal Dysplasia

  • Metaphyseal Chondrodysplasia, Shwachman Type

  • Shwachman-Diamond-Oski Syndrome
Exocrine Pancreatic Insufficiency
Bowen-Conradi Syndrome

  • BWCNS

  • Bowen Hutterite Syndrome

  • Bowen-Conradi Hutterite Syndrome

  • Bowen Syndrome, Hutterite Type

  • Bowen Hutterite Syndrome, Formerly

  • Hutterite Syndrome

  • Bowen Syndrome Hutterite Type

  • Fetal Growth Retardation
Anauxetic Dysplasia 1

  • Anauxetic Dysplasia

  • Spondylometaepiphyseal Dysplasia, Menger Type

  • Spondylometaepiphyseal Dysplasia, Anauxetic Type

  • Spondyloepimetaphyseal Dysplasia, Anauxetic Type

  • ANXD1

  • Anxd

  • Spondylometaepiphyseal Dysplasia Anauxetic Type

  • Spondylometaepiphyseal Dysplasia Menger Type

  • Ad

  • Spondyloepimetaphyseal Dysplasia, Menger Type

  • Dysplasia, Anauxetic, Type 1
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04289 EIF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus EIF6 VGNC VGNC:57006
Mus musculus EIF6 MGD MGI:1196288
Felis catus EIF6 VGNC VGNC:80091
Rattus norvegicus EIF6 RGD RGD:1305373
Macaca mulatta EIF6 VGNC VGNC:84765
Canis familiaris EIF6 VGNC VGNC:54648
Others EIF6 NCBI