MLLT6 - MLLT6, PHD finger containing Gene

Also Known as AF17

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4302

About MLLT6

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,705,273-38,729,795 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 192 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 30.7), ovary (RPKM 26.5) and 25 other tissues.

Summary

Enables histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of histone H3-K79 methylation; renal potassium excretion; and renal sodium excretion. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MLLT6 Products (1)

mRNA Protein Name
NM_005937.4 NP_005928.2 protein AF-17

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables histone binding IPI
IPI: Inferred from physical interaction
26439302 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
26439302 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLLT6 Protein Structure

PHD_2

PHD_2: PHD-finger (20 - 55)

zf-HC5HC2H_2

zf-HC5HC2H_2: PHD-zinc-finger like domain (64 - 180)

  • 0
  • 200
  • 400
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  • 800
  • 1000
  • 1093 a.a.
Protein Preferred Names Protein Names

protein AF-17

  • ALL1-fused gene from chromosome 17 protein

MLLT6 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MLLT6 P55198 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
MLLT6 P55198 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
MLLT6 P55198 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
MLLT6 P55198 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra
MLLT6 P55198 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra
MLLT6 P55198 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra
MLLT6 P55198 UBQLN4 Homo sapiens Q9NRR5
Pull Down
16713569
Intra
MLLT6 P55198 UBQLN4 Homo sapiens Q9NRR5
Y2H Array
16713569
Intra
MLLT6 P55198 PIN1 Homo sapiens Q13526
Validated Y2H
32296183
Intra
MLLT6 P55198 GRIPAP1 Homo sapiens Q4V328
Validated Y2H
32296183
Intra
MLLT6 P55198 CEBPG Homo sapiens P53567
Anti Tag CoIP
28514442
Intra
MLLT6 P55198 CEBPG Homo sapiens P53567
Anti Tag CoIP
33961781
Intra
MLLT6 P55198 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MLLT6 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83328 MLLT6 Antibody (YA3073) WB Human
HY-P83328A MLLT6 Antibody (YA3073)(PBS only) WB Human

関連疾患

Diseases Alias
Acute Megakaryoblastic Leukemia Without Down Syndrome

  • Non-Ds-Amkl
Pineal Region Germinoma

  • Pineal Germinoma
Liddle Syndrome 1

  • Liddle Syndrome

  • Pseudoaldosteronism

  • Liddle'S Syndrome

  • LIDLS1

  • Lidls

  • Pseudohyperaldosteronism

  • Pseudoprimary Hyperaldosteronism

  • Pseudohyperaldosteronism Type 1

  • Liddles Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08497 MLLT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus MLLT6 MGD MGI:1935145
Felis catus MLLT6 VGNC VGNC:68273
Canis familiaris MLLT6 VGNC VGNC:43263
Bos taurus MLLT6 VGNC VGNC:31504
Macaca mulatta MLLT6 VGNC VGNC:74883
Rattus norvegicus MLLT6 RGD RGD:1306689
Others MLLT6 NCBI