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RPL10A - ribosomal protein L10a Gene

Also Known as L10A; CSA19; NEDD6; Csa-19

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 4736

About RPL10A

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,468,401-35,470,780 (from NCBI)

This gene has 5 transcripts (splice variants), 160 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 957.8), bone marrow (RPKM 440.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL10A Products (1)

mRNA	Protein	Name
NM_007104.5	NP_009035.3	60S ribosomal protein L10a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	24725412	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL10A Protein Structure

Ribosomal_L1

0
100
200
217 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L10a	NEDD-6

RPL10A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RPL10A	P62906	RPS3A	Homo sapiens	P61247	Anti Tag CoIP	33961781
Intra	RPL10A	P62906	RPL11	Homo sapiens	P62913	Crosslink	30021884
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	25416956
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	32296183
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Y2H Array	32296183
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	25416956
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL10A 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82135	RPL10A Antibody (YA1880)	WB	Human, Mouse, Rat
HY-P82135A	RPL10A Antibody (YA1880)(PBS only)	WB	Human, Mouse, Rat

関連疾患

Diseases	Alias
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12161	RPL10A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	RPL10A	RGD	RGD:620497
Macaca mulatta	RPL10A	VGNC	VGNC:83460
Felis catus	RPL10A	VGNC	VGNC:105242
Mus musculus	RPL10A	MGD	MGI:1343877
Bos taurus	RPL10A	VGNC	VGNC:54233
Canis familiaris	RPL10A	VGNC	VGNC:105240
Others	RPL10A	NCBI