PPP1R7 - protein phosphatase 1 regulatory subunit 7 Gene

Also Known as SDS22

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5510

About PPP1R7

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,149,573-241,183,652 (from NCBI)

This gene has 20 transcripts (splice variants), 113 orthologues and 10 paralogues. Broad expression in testis (RPKM 40.9), brain (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes a protein subunit that regulates the activity of the serine/threonine Phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PPP1R7 Products (7)

mRNA Protein Name
NM_001282409.1 NP_001269338.1 protein phosphatase 1 regulatory subunit 7 isoform 2
NM_001282410.1 NP_001269339.1 protein phosphatase 1 regulatory subunit 7 isoform 3
NM_001282411.1 NP_001269340.1 protein phosphatase 1 regulatory subunit 7 isoform 4
NM_001282412.1 NP_001269341.1 protein phosphatase 1 regulatory subunit 7 isoform 5
NM_001282413.1 NP_001269342.1 protein phosphatase 1 regulatory subunit 7 isoform 6
NM_001282414.1 NP_001269343.1 protein phosphatase 1 regulatory subunit 7 isoform 7
NM_002712.3 NP_002703.1 protein phosphatase 1 regulatory subunit 7 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
23414517 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in chromosome IDA
IDA: Inferred from direct assay
22801782 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R7 Protein Structure

LRR_9

LRR_9: Leucine-rich repeat (123 - 213)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (230 - 272)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (275 - 315)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 7

  • protein phosphatase 1 regulatory subunit 22

PPP1R7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PPP1R7 Q15435 PPP1CB Homo sapiens P62140
Y2H Array
32296183
Intra
PPP1R7 Q15435 PPP1CB Homo sapiens P62140
Y2H Fragment Pooling
23414517
Intra
PPP1R7 Q15435 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
32296183
Intra
PPP1R7 Q15435 PPP1CB Homo sapiens P62140
TAP
27173435
Intra
PPP1R7 Q15435 PPP1CC Homo sapiens P36873
Anti Tag CoIP
33961781
Intra
PPP1R7 Q15435 PPP1CC Homo sapiens P36873
TAP
27173435
Intra
PPP1R7 Q15435 PPP1CA Homo sapiens P62136
Anti Tag CoIP
33961781
Intra
PPP1R7 Q15435 PPP1CA Homo sapiens P62136
TAP
27173435
Intra
PPP1R7 Q15435 PPP1CA Homo sapiens P62136
Anti Tag CoIP
28514442
Intra
PPP1R7 Q15435 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
PPP1R7 Q15435 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11003 PPP1R7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta PPP1R7 VGNC VGNC:99395
Felis catus PPP1R7 VGNC VGNC:80318
Rattus norvegicus PPP1R7 RGD RGD:1308169
Bos taurus PPP1R7 VGNC VGNC:52808
Canis familiaris PPP1R7 VGNC VGNC:59089
Mus musculus PPP1R7 MGD MGI:1913635
Others PPP1R7 NCBI