PCTP - phosphatidylcholine transfer protein Gene

Also Known as PC-TP; STARD2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 58488

About PCTP

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:55,751,051-55,852,715 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 9.3), placenta (RPKM 5.2) and 24 other tissues.

Summary

Enables phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in phospholipid transport. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PCTP Products (4)

mRNA Protein Name
NM_001102402.3 NP_001095872.1 phosphatidylcholine transfer protein isoform 2
NM_001330377.2 NP_001317306.1 phosphatidylcholine transfer protein isoform 3
NM_001330378.3 NP_001317307.1 phosphatidylcholine transfer protein isoform 4
NM_021213.4 NP_067036.2 phosphatidylcholine transfer protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatidylcholine binding IDA
IDA: Inferred from direct assay
12055623 GOA
enables phosphatidylcholine transporter activity IDA
IDA: Inferred from direct assay
12055623 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in phospholipid transport IDA
IDA: Inferred from direct assay
12055623 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCTP Protein Structure

START

START: START domain (14 - 211)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

phosphatidylcholine transfer protein

  • START domain-containing protein 2

PCTP Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PCTP Q9UKL6 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra
PCTP Q9UKL6 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-153754 Phosphatidylcholine transfer protein inhibitor-1 98.01% Unkown
HY-110260 LDN-193188 99.69% Unkown
HY-RS10178 PCTP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus PCTP RGD RGD:3276
Canis familiaris PCTP VGNC VGNC:44326
Mus musculus PCTP MGD MGI:107375
Macaca mulatta PCTP VGNC VGNC:75789
Felis catus PCTP VGNC VGNC:68738
Others PCTP NCBI