BGN - biglycan Gene

Also Known as PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 633

About BGN

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,494,980-153,509,546 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 22 paralogues and is associated with 5 phenotypes. Broad expression in gall bladder (RPKM 206.5), spleen (RPKM 159.3) and 20 other tissues.

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and Collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]

BGN Products (1)

mRNA	Protein	Name
NM_001711.6	NP_001702.1	biglycan preproprotein

BGN Protein Structure

LRRNT

LRR_8

0
100
200
300
368 a.a.

Protein Preferred Names	Protein Names
biglycan	bone/cartilage proteoglycan-I

BGN Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	BGN	P21810	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	BGN	P21810	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	BGN	P21810	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	BGN	P21810	PLEKHG4	Homo sapiens	Q58EX7-2	Y2H Array	32814053
Intra	BGN	P21810	PLEKHG4	Homo sapiens	Q58EX7-2	Validated Y2H	32814053
Intra	BGN	P21810	PLEKHG4	Homo sapiens	Q58EX7-2	Y2H Pooling	32814053
Intra	BGN	P21810	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32814053
Intra	BGN	P21810	LZTS2	Homo sapiens	Q9BRK4	Lumier	32814053
Intra	BGN	P21810	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32814053
Intra	BGN	P21810	LZTS2	Homo sapiens	Q9BRK4	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BGN Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7663	Biglycan Protein, Human (HEK293, His)	P21810 (E20-K368)	≥ 95%, as determined by reducing SDS-PAGE.

BGN 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82562	Biglycan Antibody (YA2307)	WB, IP, FC	Human, Mouse, Rat

関連疾患

Diseases	Alias
Spondyloepimetaphyseal Dysplasia, X-Linked	X-Linked Spondyloepimetaphyseal Dysplasia SEMDX Semd, X-Linked Semd X-Linked Spondyloepimetaphyseal Dysplasia X-Linked Spondylo-Epimetaphyseal Dysplasia
Meester-Loeys Syndrome	MRLS
Aortic Aneurysm, Familial Thoracic 4	AAT4 Faa4 Aortic Aneurysm/Aortic Dissection And Patent Ductus Arteriosus Familial Aortic Aneurysm 4 Non-Syndromic Thoracic Aortic Aneurysms And Dissection Taad Thoracic Aortic Aneurysms And Dissection Thoracic Aortic Aneurysms And Dissections Aneurysm, Aortic, Thoracic, Familial, Type 4
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Spondyloepimetaphyseal Dysplasia	Dysplasia, Spondyloepimetaphyseal
Carpal Tunnel Syndrome	Cts Carpal Tunnel Syndrome, Familial Carpal Tunnel Syndrome 1 CTS1 Amyotrophy, Thenar, Of Carpal Origin Carpal Tunnel Median Neuropathy Cts - Carpal Tunnel Syndrome Median Nerve Entrapment Carpal Canal Carpal Tunnel Compression Neuropathy, Carpal Tunnel Distal Median Nerve Compression Distal Median Nerve Entrapment Entrapment Neuropathy, Carpal Tunnel Median Neuropathy, Carpal Tunnel Median Neuropathy Carpal Tunnel Thenar Amyotrophy Of Crapal Origin
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Cornea Plana	Flat Cornea
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Ullrich Congenital Muscular Dystrophy 1	Ullrich Congenital Muscular Dystrophy Ullrich Disease Ucmd Ullrich Scleroatonic Muscular Dystrophy Scleroatonic Muscular Dystrophy UCMD1 Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22 Lgmdr22 Muscular Dystrophy, Scleroatonic Late Onset Scleroatonic Familial Myopathy Congenital Muscular Dystrophy, Ullrich Type
Stickler Syndrome, Type I	Stickler Syndrome 1 Stickler Syndrome Type 1 STL1 Aom Stickler Syndrome, Type 1 Stickler Syndrome, Vitreous Type 1 Stickler Syndrome, Membranous Vitreous Type Arthroophthalmopathy, Hereditary Progressive Arthro-Ophthalmopathy Hereditary Progressive Stickler Syndrome Membranous Vitreous Type Stickler Syndrome Type I Stickler Syndrome Vitreous Type 1
Tendinitis	Tendinopathy
Bethlem Myopathy 1	Bethlem Myopathy Myopathy, Benign Congenital, With Contractures Muscular Dystrophy, Benign Congenital BTHLM1 Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 5 Lgmdd5 Benign Congenital Muscular Dystrophy Benign Autosomal Dominant Myopathy Myopathy, Bethlem Myopathy, Bethlem, Type 1
Stromal Dystrophy
Brachydactyly
Geroderma Osteodysplasticum	Gerodermia Osteodysplastica Geroderma Osteodysplastica GO Walt Disney Dwarfism Type Of Gerodermia Osteodysplastica
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Collagen Disease	Collagen Diseases Collagen Disorder
Acromicric Dysplasia	ACMICD Acromicric Skeletal Dysplasia Dysplasia, Acromicric
Corneal Dystrophy, Congenital Stromal	Congenital Stromal Corneal Dystrophy CSCD Congenital Hereditary Stromal Dystrophy Congenital Hereditary Stromal Dystrophy Of The Cornea Congenital Stromal Dystrophy Of The Cornea Dacs Decorin-Associated Congenital Stromal Corneal Dystrophy Dystrophia Corneae Parenchymatosa Congenita Witschel Dystrophy Dystrophy, Corneal, Stromal, Congenital
Aortic Dissection
Hyperinsulinemic Hypoglycemia, Familial, 1	HHF1 Persistent Hyperinsulinemic Hypoglycemia Of Infancy Familial Hyperinsulinemic Hypoglycemia 1 Congenital Hyperinsulinism Phhi Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Of Infancy Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia Nesidioblastosis Of Pancreas Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis Hyperinsulinism, Congenital Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Familial, Type 1
Loeys-Dietz Syndrome	Loeys-Dietz Aortic Aneurysm Syndrome Lds Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies Furlong Syndrome
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-139162	BGN3		99.55%	Unkown
HY-RS01489	BGN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18113	Bgn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24587	Bgn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	BGN	MGD	MGI:88158
Bos taurus	BGN	VGNC	VGNC:26481
Felis catus	BGN	VGNC	VGNC:60109
Canis familiaris	BGN	VGNC	VGNC:38443
Rattus norvegicus	BGN	RGD	RGD:2207
Macaca mulatta	BGN	VGNC	VGNC:70246
Others	BGN	NCBI