TNMD - tenomodulin Gene

Also Known as TEM; CHM1L; BRICD4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 64102

About TNMD

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,584,936-100,599,885 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 1 paralogue. Biased expression in fat (RPKM 8.0), placenta (RPKM 1.2) and 2 other tissues.

Summary

This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

TNMD Products (1)

mRNA Protein Name
NM_022144.3 NP_071427.2 tenomodulin

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNMD Protein Structure

BRICHOS

BRICHOS: BRICHOS domain (94 - 186)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

tenomodulin

  • BRICHOS domain containing 4

TNMD Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TNMD Q9H2S6 TMEM79 Homo sapiens Q9BSE2
Y2H Array
25416956
Intra
TNMD Q9H2S6 TMEM79 Homo sapiens Q9BSE2
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

TNMD 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81207 TNMD Antibody WB, IHC-P, IHC-F, ICC/IF Human, Mouse, Rat

関連疾患

Diseases Alias
Epicondylitis

  • Tennis Elbow

  • Lateral Epicondylitis

  • Golfer'S Elbow

  • Medial Epicondylitis

  • Andrel Epicondylitis

  • Archer'S Elbow

  • Hockey Elbow

  • Shooter'S Elbow
Tendinitis

  • Tendinopathy
Trichothiodystrophy 6, Nonphotosensitive

  • TTD6

  • Nonphotosensitive Trichothiodystrophy 6

  • Trichothiodystrophy 6, Non-Photosensitive
Nonphotosensitive Trichothiodystrophy

  • Trichothiodystrophy Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome
Shoulder Impingement Syndrome

  • Impingement Syndrome Of Shoulder Region

  • Subacromial Impingement
Developmental And Epileptic Encephalopathy 9

  • Efmr

  • Epileptic Encephalopathy, Early Infantile, 9

  • Eiee9

  • DEE9

  • Juberg-Hellman Syndrome

  • Epilepsy, Female-Restricted, With Mental Retardation

  • Developmental And Epileptic Encephalopathy, 9

  • Early Infantile Epileptic Encephalopathy 9

  • Early Infantile Female-Limited Epilecptic Encephalopathy

  • Female Restricted Epilepsy With Mental Retardation

  • Juberg Hellman Syndrome

  • Pcdh19-Related Female-Limited Epilepsy

  • Epilepsy And Intellectual Disability Limited To Females

  • Epilepsy, Female Restricted, With Intellectual Disability

  • Familial Epilepsy And Intellectual Disability Limited To Females

  • Female Restricted Epilepsy With Intellectual Delays

  • Pcdh19-Related Fle

  • Pcdh19-Related Infantile Epileptic Encephalopathy

  • Female Restricted Epilepsy With Intellectual Disability

  • Encephalopathy, Epileptic, Early Infantile, Type 9
Bursitis

  • Bursitis, Not Otherwise Specified

  • Inflammation Of Bursa
De Quervain Disease

  • Radial Styloid Tenosynovitis

  • Tenosynovitis, De Quervain'S

  • De Quervain'S Disease

  • Tenosynovitis Of Radial Styloid Process

  • Stenosans Tenosynovitis
Calcific Tendinitis

  • Calcific Tendinitis Nos
Sclerocornea

  • Isolated Congenital Sclerocornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14846 TNMD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus TNMD VGNC VGNC:36187
Canis familiaris TNMD VGNC VGNC:47684
Macaca mulatta TNMD VGNC VGNC:79087
Mus musculus TNMD MGD MGI:1929885
Rattus norvegicus TNMD RGD RGD:620938
Others TNMD NCBI