SP2 - Sp2 transcription factor Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6668

About SP2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,896,236-47,931,731 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the Other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

SP2 Products (1)

mRNA	Protein	Name
NM_003110.6	NP_003101.3	transcription factor Sp2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10744779	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10744779	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17827154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10744779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP2 Protein Structure

zf-H2C2_2

0
100
200
300
400
500
613 a.a.

Protein Preferred Names	Protein Names
transcription factor Sp2

SP2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SP2	Q02086	MCM7	Homo sapiens	P33993	Validated Y2H	25416956
Intra	SP2	Q02086	MCM7	Homo sapiens	P33993	Y2H Array	25416956
Intra	SP2	Q02086	FHL2	Homo sapiens	Q14192	Validated Y2H	25416956
Intra	SP2	Q02086	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	SP2	Q02086	BANP	Homo sapiens	Q8N9N5	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Basidiobolomycosis	Infection By Basidiobolus Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum
Dracunculiasis	Guinea Worm Disease Dracontiasis Dracunculosis Infection By Dracunculus Medinensis Gwd Guinea Worm Infection Parasitic Infection Caused By Dracunculus Medinensis Medina Worm Disease Medinensis Medina Worm Infestation Dracunculus Medinensis Infestation Guinea Worm Infestation
Large Intestine Adenocarcinoma	Adenocarcinoma Of Large Intestine
Leukodystrophy, Hypomyelinating, 2	Pmld1 Hypomyelinating Leukodystrophy 2 HLD2 Pelizaeus-Merzbacher-Like Disease 1 Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation Pelizaeus-Merzbacher-Like Disease Type 1 Pelizaeus-Merzbacher-Like Disease, 1 Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Pmld - Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1 Pmldar1 Leukodystrophy, Hypomyelinating, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-W353469	2-O-(α-D-Glucopyranosyl)glycerol (55% in water)		99.79%	Unkown
HY-RS17158	Sp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-155176	SP-2-225	Inhibitor	/	Unkown
HY-137651A	Sp-2'-F-dATP-αS tetrasodium		/	Unkown
HY-162258	AChE-IN-57	Inhibitor	/	Unkown
HY-173132	AKR1Cs-IN-1		/	Unkown
HY-181066	ACE2-SP PPI-IN-1	Inhibitor	/	Unkown
HY-181853	NOTA-SP2A-PSMAL	Ligand	/	Unkown
HY-N10208	Aspericin C		/	Unkown
HY-P10604	SP2	Inhibitor	/	Unkown
HY-P11599	NOTA-SP2A-FAPT	Ligand	/	Unkown
HY-P5870	KTX-Sp2	Inhibitor	/	Unkown
HY-RS13605	SP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13635	SPATA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-137648A	Sp-2'-O-Me-GTPαS tetrasodium		/	Unkown
HY-137649A	Sp-2'-O-Me-CTPαS tetrasodium		/	Unkown
HY-176004	Rp-2'-Deoxyadenosine-5'-O-1-thiodiphosphate sodium		/	Unkown
HY-176005	Sp-2'-Deoxyadenosine-5'-O-1-thiodiphosphate sodium		/	Unkown
HY-N17267	2-Deoxy-20-hydroxyecdysone		/	Unkown
HY-RS23608	Sp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	SP2	MGD	MGI:1926162
Canis familiaris	SP2	VGNC	VGNC:46686
Felis catus	SP2	VGNC	VGNC:65586
Macaca mulatta	SP2	VGNC	VGNC:77845
Rattus norvegicus	SP2	RGD	RGD:1592078
Bos taurus	SP2	VGNC	VGNC:35153
Others	SP2	NCBI