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ZNF207 - zinc finger protein 207 Gene

Also Known as BuGZ; hBuGZ

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 7756

About ZNF207

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,350,157-32,381,885 (from NCBI)

This gene has 17 transcripts (splice variants) and 251 orthologues. Ubiquitous expression in bone marrow (RPKM 30.2), lymph node (RPKM 22.5) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Apr 2022]

ZNF207 Products (3)

mRNA	Protein	Name
NM_001032293.3	NP_001027464.1	BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b
NM_001098507.2	NP_001091977.1	BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform c
NM_003457.4	NP_003448.1	BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables microtubule binding	IDA IDA: Inferred from direct assay	24462186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	24462186	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	24462186	GOA
involved in mitotic spindle assembly	IDA IDA: Inferred from direct assay	26388440	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	24462186	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	24462186	GOA
involved in regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	24462186	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in kinetochore	IDA IDA: Inferred from direct assay	24462187	GOA
located in kinetochore	IMP IMP: Inferred from mutant phenotype	24462186	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24462186	GOA
located in spindle matrix	IDA IDA: Inferred from direct assay	26388440	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
BUB3-interacting and GLEBS motif-containing protein ZNF207

ZNF207 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ZNF207	O43670	BUB3	Homo sapiens	O43684	Y2H	22365833
Intra	ZNF207	O43670	BUB3	Homo sapiens	O43684	Confocal	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Chromosome 15q26-Qter Deletion Syndrome	Drayer Syndrome 15q26 Deletion Syndrome Distal 15q Deletion Syndrome Distal Monosomy 15q Telomeric 15q Deletion Syndrome Monosomy 15q26

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-161303	ZNF207-IN-1		98.03%	Unkown
HY-182358	TMLZ-G46	Inducer	/	Unkown
HY-RS16109	ZNF207 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	ZNF207	RGD	RGD:1308121
Felis catus	ZNF207	VGNC	VGNC:67275
Mus musculus	ZNF207	MGD	MGI:1340045
Macaca mulatta	ZNF207	VGNC	VGNC:78870
Bos taurus	ZNF207	VGNC	VGNC:37225
Others	ZNF207	NCBI