TRAPPC6A - trafficking protein particle complex subunit 6A Gene

Also Known as TRS33

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 79090

About TRAPPC6A

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,162,933-45,178,237 (from NCBI)

Ubiquitous expression in kidney (RPKM 18.2), spleen (RPKM 12.2) and 25 other tissues.

Summary

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

TRAPPC6A Products (4)

mRNA	Protein	Name
NM_001270891.2	NP_001257820.1	trafficking protein particle complex subunit 6A isoform 2
NM_001270892.2	NP_001257821.1	trafficking protein particle complex subunit 6A isoform 3
NM_001270893.2	NP_001257822.1	trafficking protein particle complex subunit 6A isoform 4
NM_024108.3	NP_077013.1	trafficking protein particle complex subunit 6A isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC6A Protein Structure

TRAPP

0
100
159 a.a.

Protein Preferred Names	Protein Names
trafficking protein particle complex subunit 6A	TRAPP complex subunit 6A

TRAPPC6A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Y2H Array	25416956
Intra	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Y2H Prey Pooling	25416956
Intra	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Validated Y2H	25416956
Intra	TRAPPC6A	O75865	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Array	25416956
Intra	TRAPPC6A	O75865	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
Cross	TRAPPC6A	O75865	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Cross	TRAPPC6A	O75865	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Prey Pooling	25416956
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Pull Down	16828797
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Array	31515488
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Array	25416956
Intra	TRAPPC6A	O75865	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Spondyloepiphyseal Dysplasia Tarda, X-Linked	Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Tarda SEDT Sed Tarda, X-Linked Spondyloepiphyseal Dysplasia, Late Spondyloepiphyseal Dysplasia Tarda X-Linked Sed X Linked Spondyloepiphyseal Dysplasia Tarda X-Linked Spondyloepiphyseal Dysplasia Late Onset Spondyloepiphyseal Dysplasia Sed Tarda X-Linked Sed X-Linked Sedt Dysplasia, Spondyloepiphyseal, Tarda Spondyloepiphyseal Dysplasia
Developmental And Epileptic Encephalopathy 84	DEE84 Jamuar Syndrome Eiee84 Developmental And Epileptic Encephalopathy, 84 Epileptic Encephalopathy, Early Ifantile, 84 Early Infantile Epileptic Encephalopathy 84 Epileptic Encephalopathy, Early Infantile, 84 Encephalopathy, Epileptic, Early Infantile, Type 84
Developmental And Epileptic Encephalopathy 28	DEE28 Epileptic Encephalopathy, Early Infantile, 28 Eiee28 Developmental And Epileptic Encephalopathy, 28 Early Infantile Epileptic Encephalopathy 28 Encephalopathy, Epileptic, Early Infantile, Type 28
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14993	TRAPPC6A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	TRAPPC6A	VGNC	VGNC:36292
Felis catus	TRAPPC6A	VGNC	VGNC:66514
Macaca mulatta	TRAPPC6A	VGNC	VGNC:79374
Mus musculus	TRAPPC6A	MGD	MGI:1914341
Canis familiaris	TRAPPC6A	VGNC	VGNC:47785
Rattus norvegicus	TRAPPC6A	RGD	RGD:1591735
Others	TRAPPC6A	NCBI