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CPSF7 - cleavage and polyadenylation specific factor 7 Gene

Also Known as CFIm59

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 79869

About CPSF7

This gene has 26 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 25.0), testis (RPKM 24.0) and 25 other tissues.

Summary

Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]

CPSF7 Products (3)

mRNA	Protein	Name
NM_001136040.4	NP_001129512.1	cleavage and polyadenylation specificity factor subunit 7 isoform 2
NM_001142565.3	NP_001136037.1	cleavage and polyadenylation specificity factor subunit 7 isoform 3
NM_024811.4	NP_079087.3	cleavage and polyadenylation specificity factor subunit 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA IDA: Inferred from direct assay	29276085	GOA
involved in mRNA 3'-end processing	IDA IDA: Inferred from direct assay	20695905	GOA
involved in mRNA alternative polyadenylation	IMP IMP: Inferred from mutant phenotype	20695905	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	23187700	GOA
involved in protein tetramerization	IDA IDA: Inferred from direct assay	20695905	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	19864460	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	23187700	GOA
part of mRNA cleavage factor complex	IDA IDA: Inferred from direct assay	20695905	GOA
part of mRNA cleavage factor complex	IPI IPI: Inferred from physical interaction	20695905	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19864460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF7 Protein Structure

RRM_1

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
cleavage and polyadenylation specificity factor subunit 7	CPSF 59 kDa subunit

CPSF7 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CPSF7	Q8N684	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	CPSF7	Q8N684	SMAD3	Homo sapiens	P84022	Validated Y2H	25416956
Intra	CPSF7	Q8N684	SMAD3	Homo sapiens	P84022	Y2H Array	25416956
Intra	CPSF7	Q8N684	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	26496610
Intra	CPSF7	Q8N684	NUDT21	Homo sapiens	O43809	Y2H Array	25416956
Intra	CPSF7	Q8N684	EPM2AIP1	Homo sapiens	Q7L775	Y2H Prey Pooling	25416956
Intra	CPSF7	Q8N684	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	25416956
Intra	CPSF7	Q8N684	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	25416956
Intra	CPSF7	Q8N684	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	CPSF7	Q8N684	U2AF2	Homo sapiens	P26368	Y2H	17024186
Intra	CPSF7	Q8N684	U2AF2	Homo sapiens	P26368	Pull Down	17024186
Intra	CPSF7	Q8N684	SEC23B	Homo sapiens	Q15437	Y2H Prey Pooling	25416956
Intra	CPSF7	Q8N684	SEC23B	Homo sapiens	Q15437	Validated Y2H	25416956
Intra	CPSF7	Q8N684	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	25416956
Intra	CPSF7	Q8N684	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	CPSF7	Q8N684	ARMC7	Homo sapiens	Q9H6L4	Y2H Array	25416956
Intra	CPSF7	Q8N684	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	CPSF7	Q8N684	SNRNP25	Homo sapiens	Q9BV90	Validated Y2H	25416956
Intra	CPSF7	Q8N684	SNRNP25	Homo sapiens	Q9BV90	Y2H Prey Pooling	25416956
Intra	CPSF7	Q8N684	SNRNP25	Homo sapiens	Q9BV90	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03121	CPSF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	CPSF7	MGD	MGI:1917826
Bos taurus	CPSF7	VGNC	VGNC:27675
Felis catus	CPSF7	VGNC	VGNC:61145
Macaca mulatta	CPSF7	VGNC	VGNC:71606
Rattus norvegicus	CPSF7	RGD	RGD:1305441
Canis familiaris	CPSF7	VGNC	VGNC:39578
Others	CPSF7	NCBI