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DOK3 - docking protein 3 Gene

Also Known as DOKL

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 79930

About DOK3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,501,904-177,511,100 (from NCBI)

This gene has 13 transcripts (splice variants), 122 orthologues and 7 paralogues. Biased expression in bone marrow (RPKM 31.4), spleen (RPKM 15.5) and 11 other tissues.

Summary

Predicted to be involved in Ras protein signal transduction and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in ficolin-1-rich granule membrane and plasma membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DOK3 Products (14)

mRNA	Protein	Name
NM_001144875.2	NP_001138347.1	docking protein 3 isoform 2
NM_001144876.2	NP_001138348.1	docking protein 3 isoform 3
NM_001308235.3	NP_001295164.1	docking protein 3 isoform 1
NM_001308236.3	NP_001295165.1	docking protein 3 isoform 1
NM_001375794.1	NP_001362723.1	docking protein 3 isoform 1
NM_001375795.1	NP_001362724.1	docking protein 3 isoform 1
NM_001375796.1	NP_001362725.1	docking protein 3 isoform 1
NM_001375797.2	NP_001362726.1	docking protein 3 isoform 1
NM_001375798.1	NP_001362727.1	docking protein 3 isoform 2
NM_001375799.2	NP_001362728.1	docking protein 3 isoform 2
NM_001384137.1	NP_001371066.1	docking protein 3 isoform 1
NM_001384138.1	NP_001371067.1	docking protein 3 isoform 4
NM_001384139.1	NP_001371068.1	docking protein 3 isoform 4
NM_024872.4	NP_079148.3	docking protein 3 isoform 1

DOK3 Protein Structure

IRS

0
100
200
300
400
496 a.a.

Protein Preferred Names	Protein Names
docking protein 3	Dok-like protein

DOK3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DOK3	Q7L591	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147
Intra	DOK3	Q7L591	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147
Intra	DOK3	Q7L591	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	DOK3	Q7L591	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	DOK3	Q7L591	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Histiocytic Sarcoma	Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03935	DOK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22144	Dok3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28665	Dok3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	DOK3	RGD	RGD:1311840
Canis familiaris	DOK3	VGNC	VGNC:40057
Mus musculus	DOK3	MGD	MGI:1351490
Macaca mulatta	DOK3	VGNC	VGNC:71897
Felis catus	DOK3	VGNC	VGNC:61582
Bos taurus	DOK3	VGNC	VGNC:28167
Others	DOK3	NCBI