STN1 - STN1 subunit of CST complex Gene

Also Known as AAF44; OBFC1; AAF-44; RPA-32; bA541N10.2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 79991

About STN1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,877,569-103,918,184 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 3.8), lung (RPKM 3.8) and 25 other tissues.

Summary

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

STN1 Products (1)

mRNA Protein Name
NM_024928.5 NP_079204.2 CST complex subunit STN1

STN1 Protein Structure

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (59 - 152)

STN1_2

STN1_2: CST, Suppressor of cdc thirteen homolog, complex subunit STN1 (157 - 334)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

CST complex subunit STN1

  • STN1, CST complex subunit

STN1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
STN1 Q9H668 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
STN1 Q9H668 TPP1 Homo sapiens O14773-1
Y2H
22763445
Intra
STN1 Q9H668 TEN1 Homo sapiens Q86WV5
Anti Tag CoIP
33961781
Intra
STN1 Q9H668 TEN1 Homo sapiens Q86WV5
Y2H
19854130
Intra
STN1 Q9H668 TEN1 Homo sapiens Q86WV5
Anti Tag CoIP
28514442
Intra
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3
Anti Tag CoIP
33961781
Intra
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3
Anti Tag CoIP
28514442
Intra
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3
Y2H
19854130
Intra
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3
Anti Tag CoIP
19854130
Intra
STN1 Q9H668 ACD Homo sapiens Q96AP0
BiFC
19648609
Intra
STN1 Q9H668 ACD Homo sapiens Q96AP0
Anti Tag CoIP
19648609
Intra
STN1 Q9H668 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
STN1 Q9H668 LDLRAP1 Homo sapiens Q5SW96
Anti Tag CoIP
33961781
Intra
STN1 Q9H668 LDLRAP1 Homo sapiens Q5SW96
Validated Y2H
25416956
Intra
STN1 Q9H668 LDLRAP1 Homo sapiens Q5SW96
Anti Tag CoIP
28514442
Intra
STN1 Q9H668 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STN1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70981 OBFC1 Protein, Human (His) AAH17400.1 (M1-F368) ≥ 85%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Cerebroretinal Microangiopathy With Calcifications And Cysts 2

  • CRMCC2
Cerebroretinal Microangiopathy With Calcifications And Cysts 1

  • Coats Plus Syndrome

  • Cerebroretinal Microangiopathy With Calcifications And Cysts

  • Crmcc

  • CRMCC1

  • Microangiopathy, Cerebroretinal, With Calcifications And Cysts

  • Cerebral Small Vessel Diseases
Interstitial Lung Disease 2

  • Idiopathic Pulmonary Fibrosis

  • Ipf

  • Fibrocystic Pulmonary Dysplasia

  • Pulmonary Fibrosis, Idiopathic

  • Pulmonary Fibrosis, Idiopathic, Susceptibility To

  • Cryptogenic Fibrosing Alveolitis

  • ILD2

  • Idiopathic Pulmonary Fibrosis, Familial

  • Fibrosing Alveolitis, Cryptogenic

  • Uip

  • Fibrosing Alveolitis

  • Interstitial Pneumonitis, Usual

  • Familial Idiopathic Pulmonary Fibrosis

  • Idiopathic Fibrosing Alveolitis, Chronic Form

  • Usual Interstitial Pneumonia

  • Fibrosing Alveolitis Cryptogenic

  • Hamman-Rich Disease

  • Idiopathic Pulmonary Fibrosis Familial

  • Interstitial Pneumonitis Usual

  • Fibrosis Idiopathic Pulmonary

  • Fibrosis, Pulmonary, Idiopathic

  • Hamman-Rich Syndrome

  • Chronic Idiopathic Pulmonary Fibrosis

  • Acute Interstitial Pneumonia

  • Interstitial Pulmonary Fibrosis

  • Ipf - [Idiopathic Pulmonary Fibrosis]

  • Idiopathic Lung Fibrosis

  • Fibrosing Lung Disease

  • Pulmonary Fibrosis Nos

  • Fibrosing Pneumonitis
Premature Aging

  • Syndrome With Premature-Aging
Portal Hypertension

  • Hypertension, Portal

  • Hypertension Portal

  • Pht - [Portal Hypertension]

  • Portal Htn
Pancytopenia
Spasticity
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13948 STN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13952 STON1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20340 Stn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26848 Stn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta STN1 VGNC VGNC:78219
Canis familiaris STN1 VGNC VGNC:46930
Felis catus STN1 VGNC VGNC:65791
Bos taurus STN1 VGNC VGNC:35408
Rattus norvegicus STN1 RGD RGD:1305637
Mus musculus STN1 MGD MGI:1915581
Others STN1 NCBI