RPF2 - ribosome production factor 2 homolog Gene

Also Known as BXDC1; bA397G5.4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84154

About RPF2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,982,038-111,028,263 (from NCBI)

This gene has 4 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 6.1), testis (RPKM 4.5) and 25 other tissues.

Summary

Enables 5S rRNA binding activity. Involved in protein localization to nucleolus; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RPF2 Products (2)

mRNA Protein Name
NM_001289111.2 NP_001276040.1 ribosome production factor 2 homolog isoform 2
NM_032194.3 NP_115570.1 ribosome production factor 2 homolog isoform 1

RPF2 Protein Structure

Brix

Brix: Brix domain (36 - 227)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

ribosome production factor 2 homolog

  • brix domain containing 1

RPF2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
RPF2 Q9H7B2 RRS1 Homo sapiens Q15050
Crosslink
30021884
Intra
RPF2 Q9H7B2 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
Intra
RPF2 Q9H7B2 DLG2 Homo sapiens Q15700
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Retinitis Pigmentosa 34

  • RP34
Shwachman-Diamond Syndrome 1

  • Shwachman-Diamond Syndrome

  • Shwachman Syndrome

  • Shwachman-Bodian-Diamond Syndrome

  • Sds

  • Pancreatic Insufficiency And Bone Marrow Dysfunction

  • Shwachman-Bodian Syndrome

  • SDS1

  • Lipomatosis Of Pancreas, Congenital

  • Congenital Lipomatosis Of Pancreas

  • Shwachman-Diamond Type Metaphyseal Dysplasia

  • Metaphyseal Chondrodysplasia, Shwachman Type

  • Shwachman-Diamond-Oski Syndrome
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-148349A (2R,2R)-PF-07258669 Antagonist 99.64% Unkown
HY-RS12153 RPF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20812 Rpf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27326 Rpf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris RPF2 VGNC VGNC:45710
Macaca mulatta RPF2 VGNC VGNC:83459
Felis catus RPF2 VGNC VGNC:64733
Bos taurus RPF2 VGNC VGNC:34103
Mus musculus RPF2 MGD MGI:1914489
Rattus norvegicus RPF2 RGD RGD:1306906
Others RPF2 NCBI