NUMB - NUMB endocytic adaptor protein Gene

Also Known as S171; C14orf41; c14_5527

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8650

About NUMB

Cytogenetic location: 14q24.2-q24.3 Genomic coordinates (GRCh38): 14:73,275,216-73,458,546 (from NCBI)

This gene has 28 transcripts (splice variants), 219 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 25.7), gall bladder (RPKM 21.4) and 25 other tissues.

Summary

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

NUMB Products (5)

mRNA Protein Name
NM_001005743.2 NP_001005743.1 protein numb homolog isoform 1
NM_001005744.2 NP_001005744.1 protein numb homolog isoform 2
NM_001005745.2 NP_001005745.1 protein numb homolog isoform 4
NM_001320114.2 NP_001307043.1 protein numb homolog isoform 2
NM_003744.6 NP_003735.3 protein numb homolog isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
19581412 GOA
involved in positive regulation of cell migration IGI
IGI: Inferred from genetic interaction
19581412 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19581412 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
19581412 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUMB Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (39 - 171)

NumbF

NumbF: NUMB domain (257 - 339)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 651 a.a.
Protein Preferred Names Protein Names

protein numb homolog

  • h-Numb

NUMB Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NUMB P49757 REPS1 Homo sapiens Q96D71
Pull Down
23211419
Intra
NUMB P49757 REPS1 Homo sapiens Q96D71
Anti Bait CoIP
23211419
Intra
NUMB P49757 TP53 Homo sapiens P04637
Anti Bait CoIP
18172499
Intra
NUMB P49757 TP53 Homo sapiens P04637
Anti Tag CoIP
18172499
Intra
NUMB P49757 MDM2 Homo sapiens Q00987
Anti Tag CoIP
18172499
Intra
NUMB P49757 MDM2 Homo sapiens Q00987
Anti Bait CoIP
18172499
Intra
NUMB P49757 EPS15 Homo sapiens P42566
Anti Bait CoIP
23211419
Intra
NUMB P49757 EPS15 Homo sapiens P42566
Pull Down
9303539
Intra
NUMB P49757 EPS15 Homo sapiens P42566
CoIP
9303539
Intra
NUMB P49757 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
24561623
Cross: Cross-species interaction Intra: Intraspecies interaction

NUMB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P80253 NUMB Antibody (YA258) WB, ICC/IF, IHC-P Human, Mouse, Rat

関連疾患

Diseases Alias
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Maxillary Sinus Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Maxillary Sinus

  • Adenoid Cystic Carcinoma Of The Maxillary Sinus
Tarp Syndrome

  • TARPS

  • Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot

  • Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome

  • Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome

  • Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome

  • Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava

  • Pierre Robin Sequence - Congenital Heart Defect - Talipes

  • Pierre Robin Syndrome - Congenital Heart Defect - Talipes

  • Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava

  • Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Tactile Agnosia
Pericoronitis

  • Operculitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-119734 Gossypolone 96.28% Unkown
HY-N7013 Hydroxy-Epsilon-Sanshool / Unkown
HY-N7014 Hydroxyl-​γ-​isosanshool / Unkown
HY-RS09681 NUMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19926 Numb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26428 Numb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus NUMB MGD MGI:107423
Macaca mulatta NUMB VGNC VGNC:75557
Felis catus NUMB VGNC VGNC:68596
Canis familiaris NUMB VGNC VGNC:49933
Rattus norvegicus NUMB RGD RGD:620107
Bos taurus NUMB VGNC VGNC:50234
Others NUMB NCBI