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EIF3A - eukaryotic translation initiation factor 3 subunit A Gene

Also Known as EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 8661

About EIF3A

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,033,670-119,080,817 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues.

Summary

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3A Products (1)

mRNA	Protein	Name
NM_003750.4	NP_003741.1	eukaryotic translation initiation factor 3 subunit A

EIF3A Protein Structure

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1382 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 3 subunit A	EIF3, p180 subunit

EIF3A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	EIF3A	Q14152	EIF1AX	Homo sapiens	P47813	Pull Down	23623729
Intra	EIF3A	Q14152	KRT7	Homo sapiens	P08729	Y2H	11169732
Intra	EIF3A	Q14152	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	EIF3A	Q14152	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	EIF3A	Q14152	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	GMS	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	3D-EM	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	Ion Exchange Chrom	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	Anti Bait CoIP	17353931
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	TEM	23623729
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	SLCA	18599441
Intra	EIF3A	Q14152	EIF3E	Homo sapiens	P60228	Pull Down	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	GMS	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	SLCA	18599441
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	3D-EM	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	TEM	23623729
Intra	EIF3A	Q14152	EIF3C	Homo sapiens	Q99613	Ion Exchange Chrom	23623729
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	Anti Bait CoIP	11169732
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	Pull Down	11169732
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	Y2H	11169732
Intra	EIF3A	Q14152	EIF3B	Homo sapiens	P55884	SLCA	18599441
Intra	EIF3A	Q14152	UPF1	Homo sapiens	Q92900-2	Anti Bait CoIP	18423202
Intra	EIF3A	Q14152	EIF1	Homo sapiens	P41567	Pull Down	23623729

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF3A 抗体

製品番号	製品名	アプリケーション	反応性
HY-P87156	eIF3A Antibody (YA6849)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

関連疾患

Diseases	Alias
Craniotubular Dysplasia, Ikegawa Type	CTDI Craniotubular Dysplasia Ikegawa Type Doid:0112340
Diphyllobothriasis	Diphyllobothrium Infection Fish Tapeworm Bothriocephalosis Infection By Bothriocephalus Fish Tapeworm Infection Dibothriocephalus Anaemia Dibothriocephaliasis Broad Tapeworm Infection Bothriocephaliasis Dibothriocephalus Intestinal Diphyllobothriasis Diphyllobothrium Infestation Dibothriocephalus Infestation Bothriocephalus Infestation Adult Diphyllobothrium Infection Tapeworm Anaemia Infection By Diphyllobothrium Larvae
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS04289	EIF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04257	EIF3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	EIF3A	RGD	RGD:1307269
Felis catus	EIF3A	VGNC	VGNC:61780
Bos taurus	EIF3A	VGNC	VGNC:28392
Canis familiaris	EIF3A	VGNC	VGNC:40268
Mus musculus	EIF3A	MGD	MGI:95301
Others	EIF3A	NCBI