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製品番号: HY-N19212

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Glenthmycin A

Glenthmycin A is a macrocyclic type II spiroketal polyketide antibacterial agent. Glenthmycin A inhibits the growth of Gram-positive pathogens. Glenthmycin A is applicable to the research of bacterial infections.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3040055-59-9
分子式: C₄₉H₆₃NO₁₃
分子量:874.04

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glenthmycin A 構造式

CAS 番号: 3040055-59-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	IC₅₀	30 μM Compound: 1	Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]
SW-620	IC₅₀	30 μM Compound: 1	Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]

体外実験

Anti-cancerBacterial Infection

Anti-cancer

Glenthmycin A (30 μM; 48 h) does not exhibit significant cytotoxicity against human colorectal carcinoma (SW620) or human lung carcinoma (NCI-H460) cells, with IC₅₀ > 30 μM^[1].

Bacterial Infection

Glenthmycin A (Compound 1) (0.01-30 μM; 16-24 h) inhibits the growth of S. aureus ATCC 25923 (IC₅₀ 6.4 μM), E. faecalis (IC₅₀ 5.7 μM), MRSA ATCC 43300 (IC₅₀ 4.4 μM), MRSA ATCC 33591 (IC₅₀ 1.9 μM), and VRE (IC₅₀ 5.2 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 3040055-59-9
分子量 874.04
分子式 C₄₉H₆₃NO₁₃
SMILES

OC=1[C@@]23[C@@](C=C(C(O)=O)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](O[C@H]6[C@H](O)[C@](C)(O)[C@H](NC(=O)C7=C(C)C=C(OC)C=C7O)[C@@H](C)O6)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
Structure Classification
- Others
Initial Source
- Microorganism
Streptomyces sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wu T, et al. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. J Nat Prod. 2022 Jun 24;85(6):1641-1657. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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