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United States

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製品番号: HY-161877

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GS-7682

GS-7682 is an antiviral compound. GS-7682 has inhibitory activity against pneumoviruses and picornaviruses. GS-7682 can be used in the study of respiratory diseases such as asthma and chronic obstructive pulmonary disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2694736-39-3
分子式: C₃₀H₃₇N₆O₁₀P
分子量:672.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GS-7682 構造式

CAS 番号: 2694736-39-3

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	21.1 μM Compound: 1; GS-7682	Cytotoxicity against human A549 cells expressing hACE2 incubated for 28 hrs by Cell Titer Glo assay Cytotoxicity against human A549 cells expressing hACE2 incubated for 28 hrs by Cell Titer Glo assay	[PMID: 39018526]
Epithelial cell	CC₅₀	8.3 μM Compound: 1; GS-7682	Cytotoxicity against Normal human bronchial epithelial cells Cytotoxicity against Normal human bronchial epithelial cells	[PMID: 39018526]
H1-HeLa	CC₅₀	22.2 μM Compound: 1; GS-7682	Cytotoxicity against human H1-HeLa cells incubated for 96 hrs by Cell Titer Glo assay Cytotoxicity against human H1-HeLa cells incubated for 96 hrs by Cell Titer Glo assay	[PMID: 39018526]
HEp-2	CC₅₀	22.7 μM Compound: 1; GS-7682	Cytotoxicity against human Hep-2 cells incubated for 4 to 5 days by Cell Titer Glo assay Cytotoxicity against human Hep-2 cells incubated for 4 to 5 days by Cell Titer Glo assay	[PMID: 39018526]
LLC-MK2	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against rhesus monkey LLC-MK2 cells incubated for 5 days by MTS assay Cytotoxicity against rhesus monkey LLC-MK2 cells incubated for 5 days by MTS assay	[PMID: 39018526]
MDCK	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against MDCK cells by MTS assay Cytotoxicity against MDCK cells by MTS assay	[PMID: 39018526]
MT4	CC₅₀	3.24 μM Compound: 1; GS-7682	Cytotoxicity against human MT4 cells incubated for 5 days by Cell Titer Glo assay Cytotoxicity against human MT4 cells incubated for 5 days by Cell Titer Glo assay	[PMID: 39018526]
RD	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against human RD cells by MTS assay Cytotoxicity against human RD cells by MTS assay	[PMID: 39018526]

化学情報

CAS 番号 2694736-39-3
分子量 672.62
分子式 C₃₀H₃₇N₆O₁₀P
SMILES

O=[P@](N[C@@H](C)C(OC)=O)(OC1=CC=CC=C1)OC[C@]2(C#N)[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@H](C3=CC=C4N3N=CN=C4N)O2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Siegel DS, et al. Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. J Med Chem. 2024 Jul 17. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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