country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-149263

Copy Link Print Information

HAA-09

HAA-09 is an orally active and potent anti-influenza agent, targeting the influenza PB2_cap binding domain. HAA-09 displays potent anti-influenza A virus activity, with an EC₅₀ of 0.03 μM. HAA-09 shows polymerase inhibition, with an IC₅₀ of 0.06±0.004 μM. HAA-09 blocks virus replication without causing obvious cytotoxicity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1422051-33-9
分子式: C₁₇H₁₈F₂N₆O₂
分子量:376.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

HAA-09 構造式

CAS 番号: 1422051-33-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC50: 0.06±0.004 μM (polymerase); EC50: 0.03 μM (influenza A virus)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: HAA-09	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by CCK-8 method Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by CCK-8 method	[PMID: 36773549]

体外実験

HAA-09 exhibits a stronger antiviral activity against oseltamivir-sensitive A/WSN/33 and oseltamivir-resistant H275Y variant, superior to oseltamivir^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

HAA-09 exhibits high plasma stability (t_1/2≥12 h) and no obvious hERG inhibition^[1].
HAA-09 (0-25 mg/kg; Orally, BID) exhibits anti-influenza virus efficacy in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/C mice^[1]
Dosage:

40 mg/kg
Administration:

Orally, QD (once daily) for consecutive 3 days
Result:

Demonstrated a favorable safety profile when orally administrated in healthy mice.

Animal Model:

Female BALB/c mice (6–8 weeks)^[1]
Dosage:

12.5, 25 mg/kg
Administration:

Orally, BID (twice daily) starting 48 h post infection for 9 days
Result:

Demonstrated in vivo therapeutic efficacy (85.7% survival observed at the day 15 post infection).

化学情報

CAS 番号 1422051-33-9
分子量 376.36
分子式 C₁₇H₁₈F₂N₆O₂
SMILES

CC(C)(N(NC1=C(C=NC(C2=CNC3=C2C=C(C=N3)F)=N1)F)CC(O)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang S, et al. Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit. Eur J Med Chem. 2023 Mar 15;250:115185. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ