HEPPS
Based on 1 Customer Validation
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.04%
- CAS 番号: 16052-06-5
- 分子式: C9H20N2O4S
- 分子量:252.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
HEPPS (0-25 μM, 7 days) binds to amyloid-β aggregates and convert them into monomers, thereby reducing the formation of amyloid-β oligomers and plaques. HEPPS rescues cell damage induced by amyloid-β aggregates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-22
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Concentration:25 μM
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Incubation Time:7 days
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Result:Improved the cell viability decreased by amyloid-β oligomers.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:APP/PS1 double transgenic mouse model[1]
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Dosage:30 mg/kg/day
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Administration:po, in drinking water for 3.5 months
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Result:Improved the contextual fear memory deficit, spatial reference memory deficit and spatial working memory deficit of mice.
Reduced Ab oligomer and plaque deposition in the brain of mice.
Reduced glial GABA release in the brain of mice.
化学情報
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CAS 番号 16052-06-5
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性状 Solid
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分子量 252.33
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分子式 C9H20N2O4S
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Color White to off-white
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SMILES
O=S(CCCN1CCN(CCO)CC1)(O)=O
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別名
EPPS
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
H2O : 233.33 mg/mL (924.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (396.31 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.9631 mL | 19.8153 mL | 39.6306 mL | 99.0766 mL |
| 5 mM | 0.7926 mL | 3.9631 mL | 7.9261 mL | 19.8153 mL | |
| 10 mM | 0.3963 mL | 1.9815 mL | 3.9631 mL | 9.9077 mL | |
| 15 mM | 0.2642 mL | 1.3210 mL | 2.6420 mL | 6.6051 mL | |
| 20 mM | 0.1982 mL | 0.9908 mL | 1.9815 mL | 4.9538 mL | |
| 25 mM | 0.1585 mL | 0.7926 mL | 1.5852 mL | 3.9631 mL | |
| 30 mM | 0.1321 mL | 0.6605 mL | 1.3210 mL | 3.3026 mL | |
| 40 mM | 0.0991 mL | 0.4954 mL | 0.9908 mL | 2.4769 mL | |
| 50 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9815 mL | |
| 60 mM | 0.0661 mL | 0.3303 mL | 0.6605 mL | 1.6513 mL | |
| 80 mM | 0.0495 mL | 0.2477 mL | 0.4954 mL | 1.2385 mL | |
| 100 mM | 0.0396 mL | 0.1982 mL | 0.3963 mL | 0.9908 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
HEPPS 関連分類
HY-D0873 関連分類
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