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製品番号: HY-182712

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HPSE-IN-2

HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 53859-71-5
分子式: C₂₇H₂₀N₆O
分子量:444.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPSE-IN-2 構造式

CAS 番号: 53859-71-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B16	Inhibition	50 % Compound: 7a	Inhibition of proliferation on B16-BL6 melanoma cells at 100 uM Inhibition of proliferation on B16-BL6 melanoma cells at 100 uM	[PMID: 16246560]

体内実験

HPSE-IN-2 (Compound 12a) (30 mg/kg; i.p.; single dose) inhibits B16 melanoma lung metastasis in C57 mice by approximately 50%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57 (experimental metastasis model via tail vein injection of B16 melanoma cells)^[1]
Dosage:

30 mg/kg
Administration:

i.p.; single dose
Result:

Inhibited lung metastasis by approximately 50% compared to the vehicle-treated group.

化学情報

CAS 番号 53859-71-5
分子量 444.49
分子式 C₂₇H₂₀N₆O
SMILES

O=C(NC1=CC=C(C2=NC3=C(N2)C=CC=C3)C=C1)NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Miao HQ, et al. Development of heparanase inhibitors for anti-cancer therapy. Curr Med Chem. 2006;13(18):2101-2111. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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