HS024 TFA
Based on 1 publication(s) in Google Scholar
HS024 TFA is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 TFA blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 TFA induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 TFA can be used in research related to MC4 receptor-mediated diseases, such as eating disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.80%
- 分子式: C58H79N19O10S2·xC2HF3O2
- 分子量:1266.50 (free base)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 HS024 TFA
More
生物活性
製品説明
IC50 & Target
[1]|
MC4R 0.29 nM (Ki) |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
HS024 (0.02-0.1 nmol; i.c.v.; single injection 20 min before testing) TFA does not alter exploratory/locomotor activity in the elevated plus maze or open field[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 1266.50 (free base)
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分子式 C58H79N19O10S2·xC2HF3O2
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Color White to off-white
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配列
Ac-Cys-{Nle}-Arg-His-{D-2Nal}-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge:Cys1-Cys9)
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シーケンスの短縮
Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
A microglial LCN2-MC4R signaling axis drives silica-induced neuronal damage via C1q release. [Abstract]2026 Jan 23;23(1):70. PMID: 41578331
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (Need ultrasonic)
純度とドキュメンテーション
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データシート (295 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HS024 TFA 関連分類
HY-P1215A 関連分類
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