HS024
Based on 1 publication(s) in Google Scholar
HS024 is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 can be used in research related to MC4 receptor-mediated diseases, such as eating disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 212370-59-7
- 分子式: C58H79N19O10S2
- 分子量:1266.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-P0227
SHU 9119MC3/4R Antagonist -
HY-N2466
Melanotan IMelanocortin Receptor Activator -
HY-P1211
Adrenocorticotropic Hormone (ACTH) (1-39), humanMelanocortin Receptor Agonist -
![[D-Trp8]-γ-MSH](https://file.medchemexpress.com/product_pic/hy-p1217.gif)
HY-P1217
[D-Trp8]-γ-MSHMC3 Agonist -
HY-P1531
γ-1-Melanocyte Stimulating Hormone (MSH), amideMelanocortin Receptor Agonist -
HY-P0252
α-MSHMC4R Agonist -
HY-P1214
γ1-MSHMC3 Receptor Agonist -
HY-P0267
Melanotan (MT)-IIMelanotropin Receptor Agonist -
HY-P1213
JKC363MC4 Receptor Antagonist -
HY-10624
THIQMC4R Agonist -
HY-P1208
PG-931Melanocortin 4 Receptor Agonist -
HY-107627
MCL0020MC4 Receptor Antagonist
MedChemExpress（MCE）の使用を引用している文献 HS024
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生物活性
製品説明
IC50 & Target
[1]|
MC4R 0.29 nM (Ki) |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
HS024 (0.02-0.1 nmol; i.c.v.; single injection 20 min before testing) does not alter exploratory/locomotor activity in the elevated plus maze or open field[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (adult male, 330-380 g at time of surgery)[1]
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Dosage:0.1 nmol, 0.3 nmol, 1.0 nmol
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Administration:i.c.v.; single injection per test day; repeated every third day in randomized order
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Result:Produced dose‑dependent orexigenic effects following intracerebroventricular administration.
Exhibited delayed onset: only 1 nmol stimulated food intake at 1 h; all doses elevated intake from 2‑4 h.
Achieved maximal 4‑fold feeding stimulation at 1 nmol, with 6‑8 g food consumed by rats within 4 h.
Triggered dose‑dependent food spillage, significant at 0.33 nmol and 1.0 nmol.
Showed no significant alteration in % spillage/CFI ratio.
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Animal Model:Wistar (adult male, 330-380 g at time of surgery)[1]
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Dosage:0.02 nmol, 0.1 nmol
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Administration:i.c.v.; single injection 20 min before elevated plus-maze/open-field testing
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Result:Detected no overall anxiety‑related behavioral differences versus saline at 0.02 nmol and 0.1 nmol.
Observed comparable horizontal‑vertical open‑field locomotion across both doses.
Noted higher fecal‑boli counts solely for 0.02 nmol in elevated‑plus‑maze testing.
Found unaltered fecal‑boli output in open‑field assay for both doses.
化学情報
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CAS 番号 212370-59-7
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分子量 1266.50
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分子式 C58H79N19O10S2
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配列
Ac-Cys-{Nle}-Arg-His-{D-2Nal}-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge:Cys1-Cys9)
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シーケンスの短縮
Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
A microglial LCN2-MC4R signaling axis drives silica-induced neuronal damage via C1q release. [Abstract]2026 Jan 23;23(1):70. PMID: 41578331
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HS024 関連分類
HY-P1215 関連分類
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