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製品番号: HY-147784

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HZ-A-005

HZ-A-005 is a potent, selective, and covalent Bruton’s tyrosine kinase (BTK) inhibitor. HZ-A-005 markedly decreases tumor growth in xenograft mouse models.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2041789-14-2
分子式: C₂₅H₂₃ClN₆O₂
分子量:474.94

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HZ-A-005 構造式

CAS 番号: 2041789-14-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HZ-A-005 is a potent, selective, and covalent Bruton’s tyrosine kinase (BTK) inhibitor. HZ-A-005 markedly decreases tumor growth in xenograft mouse models^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	0.22 μM Compound: 42	Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33740548]
HEK293	IC₅₀	5.46 μM Compound: 42	Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability by MTT assay	[PMID: 33740548]
L02	IC₅₀	15.93 μM Compound: 42	Antiproliferative activity against human L02 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability by MTT assay	[PMID: 33740548]
OCI-Ly10	IC₅₀	0.16 μM Compound: 42	Antiproliferative activity against human OCILY10 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human OCILY10 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33740548]
Rec1	IC₅₀	0.01 μM Compound: 42	Antiproliferative activity against human REC1 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human REC1 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33740548]

化学情報

CAS 番号 2041789-14-2
分子量 474.94
分子式 C₂₅H₂₃ClN₆O₂
SMILES

C=C(C(N1CCC[C@@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5)=O)Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Huang W, et al. HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development. Bioorg Chem. 2020;105:104377. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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