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製品番号: HY-122226

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IC-87361

IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC₅₀ of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 404011-02-5
分子式: C₁₉H₁₇NO₄
分子量:323.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

IC-87361 構造式

CAS 番号: 404011-02-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
C8166	EC₅₀	>200 μg/mL Compound: 5c	Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis	[PMID: 24794743]

体外実験

IC-87361 selectively radiosensitises DNA-PK-competent wild-type endothelial cells, lung cancer cells, and melanoma cells, and enhances radiation-induced apoptosis in lung cancer and melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

IC-87361 acts as a radiosensitizer to enhance ionizing radiation-induced tumour growth delay in human lung cancer xenografts, with a partial effect on tumour vasculature^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 404011-02-5
分子量 323.35
分子式 C₁₉H₁₇NO₄
SMILES

O=C1C=C(OC2=CC(=CC(O)=C12)N3CCOCC3)C=4C=CC=CC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Curtin N, et al. Therapeutic potential of drugs to modulate DNA repair in cancer. Expert Opin Ther Targets. 2007;11(6):783-799. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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