Icanbelimod
Based on 1 Customer Validation
Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 1514888-56-2
- 分子式: C23H24FN3O3
- 分子量:409.45
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Immunology/Inflammation Compound Library
HY-L007
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Orally Active Compound Library
HY-L061
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Targeted Diversity Library
HY-L099
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Heterocyclic Compound Library
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
HY-L249
生物活性
EC50: 9.83 nM (S1P1 internalization)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis rats[1]
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Dosage:3 mg/kg
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Administration:Oral administration
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Result:Decreased the severity score of arthritis in the four-legged rats.
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Animal Model:Female C57BL/6 mice[1]
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Dosage:0.03, 0.1, and 1 mg/kg
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Administration:Oral administration
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Result:Decreased the severity score of EAE in MOG 35-55 induced mice.
化学情報
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CAS 番号 1514888-56-2
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性状 Solid
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分子量 409.45
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分子式 C23H24FN3O3
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Color White to off-white
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SMILES
O=C(C1CN(CC2=CC=C(C3=NOC(C4=CC=C(CC(C)C)C=C4)=N3)C=C2F)C1)O
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別名
S1p receptor agonist 1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 6.8 mg/mL (16.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4423 mL | 12.2115 mL | 24.4230 mL | 61.0575 mL |
| 5 mM | 0.4885 mL | 2.4423 mL | 4.8846 mL | 12.2115 mL | |
| 10 mM | 0.2442 mL | 1.2212 mL | 2.4423 mL | 6.1058 mL | |
| 15 mM | 0.1628 mL | 0.8141 mL | 1.6282 mL | 4.0705 mL |
Icanbelimod 関連分類
HY-101265 関連分類
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