IMM-H012
IMM-H012 is a specific PI3K inhibitor with an IC50 of 0.80 nM against PI3Kα. IMM-H012 combined with [177Lu]Lu-P4 shows synergistic antitumor effects against stomach cancer and lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2231399-03-2
- 分子式: C26H25F2N5O5S
- 分子量:557.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PI3K 0.80 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.053 μM
Compound: 19
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Cytotoxicity against human A549 cells after 96 hrs by MTT assay
Cytotoxicity against human A549 cells after 96 hrs by MTT assay
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[PMID: 29927604] |
IMM-H012 potently inhibits PI3Kα kinase activity with an IC50 of 0.80 nM[1].
IMM-H012 (IC50 of 0.514 μM) inhibits MKN-45 gastric cancer cell proliferation[1].
IMM-H012 modulates PI3K pathway gene expression in MKN-45 cells by downregulating PIK3CA and PIK3CB while upregulating compensatory PIK3CD and PIK3R3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2231399-03-2
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分子量 557.57
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分子式 C26H25F2N5O5S
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SMILES
CC1=NC(N)=NC2=C1C=C(C3=CC(NS(C4=C(F)C=C(F)C=C4)(=O)=O)=C(OC)N=C3)C=C2OC5CCOCC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
IMM-H012 関連分類
HY-181581 関連分類
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