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製品番号: HY-N10304

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Isodispar B

Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 98192-64-4
分子式: C₂₀H₁₈O₅
分子量:338.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Isodispar B 構造式

CAS 番号: 98192-64-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	4 μg/mL Compound: 23	Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay	[PMID: 27494166]
MCF7	GI₅₀	1.5 μg/mL Compound: 13	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15787438]
NCI-H460	GI₅₀	1.9 μg/mL Compound: 13	Cytotoxicity against human H460 cells Cytotoxicity against human H460 cells	[PMID: 15787438]
SF-268	GI₅₀	1.8 μg/mL Compound: 13	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 15787438]

体外実験

Isodispar B (compound 1) (0-100 μM; 72 h) exerts a broad spectrum of anti-cancer activity to inhibit cell proliferation with IC₅₀s of 3.84-56.73 μM^[1].
Isodispar B (1 μM and 10 μM; 3 d) induces apoptosis on nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460)
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.

化学情報

CAS 番号 98192-64-4
分子量 338.35
分子式 C₂₀H₁₈O₅
SMILES

O=C1C=C(C2=CC=CC=C2)C3=C(O)C=C(O)C(C(CC(C)C)=O)=C3O1
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lim C K, et al. In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species[J]. Medicinal Chemistry Research, 2016, 25(8): 1686-1694.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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