J 104871
J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of farnesyl pyrophosphate (FPP).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 191088-19-4
- 分子式: C38H32N2O12
- 分子量:708.67
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of 0.6 μM farnesyl pyrophosphate (FPP), whereas it scarcely inhibits rat brain protein geranylgeranyltransferase-I or squalene synthase (SS)[1].
J 104871 also inhibits Ras processing in activated H-ras-transformed NIH3T3 cells with an IC50 value of 3.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nude mice (8 weeks old) injected activated H-ras-transformed NIH3T3 cells [1]
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Dosage:40 mg/kg, 80 mg/kg
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Administration:ip; once daily; 6 days
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Result:Suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
化学情報
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CAS 番号 191088-19-4
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分子量 708.67
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分子式 C38H32N2O12
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SMILES
O=C(C1(C(O)=O)O[C@H](C(N([C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)C/C=C/C4=NC5=CC=CC=C5O4)CC6=CC=C7C=CC=CC7=C6)=O)[C@H](C(O)=O)O1)O
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別名
J-104135
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
J 104871 関連分類
HY-19301 関連分類
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